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dc.contributor.authorSlob, Wout
dc.contributor.authorSoeteman-Hernández, Lya G
dc.contributor.authorWieneke , Bil
dc.contributor.authorStaal, Yvonne C M
dc.contributor.authorStephens, William E
dc.contributor.authorTalhout, Reinskje
dc.date.accessioned2020-05-05T13:30:03Z
dc.date.available2020-05-05T13:30:03Z
dc.date.issued2020-05-01
dc.identifier.citationSlob , W , Soeteman-Hernández , L G , Wieneke , B , Staal , Y C M , Stephens , W E & Talhout , R 2020 , ' A method for comparing the impact on carcinogenicity of tobacco products : a case study on heated tobacco versus cigarettes ' , Risk Analysis , vol. Early View . https://doi.org/10.1111/risa.13482en
dc.identifier.issn1539-6924
dc.identifier.otherPURE: 267091855
dc.identifier.otherPURE UUID: be021287-ec21-4381-bfef-82258b72af76
dc.identifier.otherORCID: /0000-0002-0884-8722/work/73700698
dc.identifier.otherScopus: 85084244238
dc.identifier.otherWOS: 000529603900001
dc.identifier.urihttp://hdl.handle.net/10023/19883
dc.descriptionThis work was funded by the Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, The Netherlands.en
dc.description.abstractComparing the harmful health effects related to two different tobacco products by applying common risk assessment methods to each individual compound is problematic. We developed a method that circumvents some of these problems by focusing on the change in cumulative exposure (CCE) of the compounds emitted by the two products considered. The method consists of six steps. The first three steps encompass dose‐response analysis of cancer data, resulting in relative potency factors with confidence intervals. The fourth step evaluates emission data, resulting in confidence intervals for the expected emission of each compound. The fifth step calculates the change in CCE, probabilistically, resulting in an uncertainty range for the CCE. The sixth step estimates the associated health impact by combining the CCE with relevant dose‐response information. As an illustrative case study, we applied the method to eight carcinogens occurring both in the emissions of heated tobacco products (HTPs), a novel class of tobacco products, and tobacco smoke. The CCE was estimated to be 10‐ to 25‐fold lower when using HTPs instead of cigarettes. Such a change indicates a substantially smaller reduction in expected life span, based on available dose‐response information in smokers. However, this is a preliminary conclusion, as only eight carcinogens were considered so far. Furthermore, an unfavorable health impact related to HTPs remains as compared to complete abstinence. Our method results in useful information that may help policy makers in better understanding the potential health impact of new tobacco and related products. A similar approach can be used to compare the carcinogenicity of other mixtures.
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofRisk Analysisen
dc.rightsCopyright © 2020 The Authors. Risk Analysis published by Wiley Periodicals, Inc. on behalf of Society for Risk Analysis This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectTobacco productsen
dc.subjectCarcinogenicityen
dc.subjectHeated tobaccoen
dc.subjectCumulative exposureen
dc.subjectRelative potencyen
dc.subjectRA Public aspects of medicineen
dc.subject3rd-DASen
dc.subject.lccRAen
dc.titleA method for comparing the impact on carcinogenicity of tobacco products : a case study on heated tobacco versus cigarettesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Earth & Environmental Sciencesen
dc.identifier.doihttps://doi.org/10.1111/risa.13482
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-05-01


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