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dc.contributor.authorSobczak, Amélie I. S.
dc.contributor.authorBlindauer, Claudia A.
dc.contributor.authorStewart, Alan J.
dc.date.accessioned2019-08-28T13:30:02Z
dc.date.available2019-08-28T13:30:02Z
dc.date.issued2019-08-28
dc.identifier.citationSobczak , A I S , Blindauer , C A & Stewart , A J 2019 , ' Changes in plasma free fatty acids associated with type-2 diabetes ' , Nutrients , vol. 11 , no. 9 , 2022 . https://doi.org/10.3390/nu11092022en
dc.identifier.issn2072-6643
dc.identifier.otherPURE: 260828968
dc.identifier.otherPURE UUID: d223cb72-41e9-49cf-ab53-32800129291e
dc.identifier.otherScopus: 85071736222
dc.identifier.otherWOS: 000487964600116
dc.identifier.urihttp://hdl.handle.net/10023/18387
dc.descriptionThis research was funded by the British Heart Foundation, grant numbers PG/15/9/31270 and FS/15/42/3155 and by the Leverhulme Trust, grant number RPG-2017-214.en
dc.description.abstractType 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid (FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms by which the plasma FFA profile of subjects with T2DM changes is unclear, but it is thought that dietary fats and changes to lipid metabolism are likely to contribute. Therefore, establishing the changes in concentrations of specific FFAs in an individual’s plasma is important. Each type of FFA has different effects on physiological processes, including the regulation of lipolysis and lipogenesis in adipose tissue, inflammation, endocrine signalling and the composition and properties of cellular membranes. Alterations in such processes due to altered plasma FFA concentrations/profiles can potentially result in the development of insulin resistance and coagulatory defects. Finally, fibrates and statins, lipid-regulating drugs prescribed to subjects with T2DM, are also thought to exert part of their beneficial effects by impacting on plasma FFA concentrations. Thus, it is also interesting to consider their effects on the concentration of FFAs in plasma. Collectively, we review how FFAs are altered in T2DM and explore the likely downstream physiological and pathological implications of such changes.
dc.format.extent42
dc.language.isoeng
dc.relation.ispartofNutrientsen
dc.rightsCopyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectCardiovascular diseaseen
dc.subjectFibratesen
dc.subjectFree fatty acidsen
dc.subjectLipidomicsen
dc.subjectMetabolismen
dc.subjectStatinsen
dc.subjectType-2 diabetes mellitusen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subject.lccRA0421en
dc.titleChanges in plasma free fatty acids associated with type-2 diabetesen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews.Cellular Medicine Divisionen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.3390/nu11092022
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.mdpi.com/2072-6643/11/9/2022en


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