Now showing items 1-10 of 38
(University of St Andrews, 2018-06-27) - Thesis
Nitric oxide donors for the treatment of prostate cancer
(University of St Andrews, 2013-11-29) - Thesis
Chapter One provides a general introduction into the biology and chemistry of nitric oxide, with particular focus on the role of nitric oxide in cardiovascular disease, cancer and hypoxia. It also details the types of ...
Exploring the substrate scope of the fluorinase from Streptomyces cattleya for applications to positron emission tomography
(University of St Andrews, 2015-11-30) - Thesis
The fluorinase enzyme, originally isolated from Streptomyces cattleya, has the unique ability to generate a C–F bond from aqueous fluoride ion and S-adenosylmethionine, making the fluorinase an attractive biochemical tool ...
Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers
(2016-07-25) - Journal article
We report a last-step fluorinase-catalyzed [18F]-fluorination of a cysteine-containing RGD peptide. The peptide was attached through sulfur to a modified and more hydrophilic variant of the recently disclosed Barbas linker ...
Molecular probes for the evaluation of three isomerase enzyme mechanisms in secondary metabolism
(University of St Andrews, 2010) - Thesis
This thesis is focused on an investigation of the mechanisms of three enzymatically mediated carbon skeleton isomerisation reactions. Chapter 1 provides an overview of some representative examples of the carbon skeleton ...
Synthesis studies to single stereoisomers of the vicinal trifluoroalkane motif
(University of St Andrews, 2009) - Thesis
This thesis focuses on the construction of individual isomers of the R-CHF-CHF-CHF-R’ motif. The multi-vicinal fluorine motif is new in organic chemistry and therefore stereoselective methods giving rapid access to these ...
Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase
(2016-03-21) - Journal article
The substrate scope of fluorinase enzyme mediated transhalogenation reactions is extended. Substrate tolerance allows a peptide cargo to be tethered to a 5'-chloro-5'-deoxynucleoside substrate for transhalogenation by the ...
Strategies for radiolabelling antibody, antibody fragments and affibodies with fluorine-18 as tracers for positron emission tomography (PET)
(2017-11) - Journal item
The use of fluorine-18 as a radionuclide for positron emission tomography (PET) has become increasingly popular over the last two decades and cancer and neurology clinical centres worldwide are increasingly establishing ...
First syntheses of fluoromuscimols
(University of St Andrews, 2017-06-21) - Thesis
Chapter 1 provides a general introduction on the role of bioisosterism of fluorine aiming to improve the pharmacokinetics properties of lead compounds. GABAA receptors specifically, synaptic GABAA receptors, extrasynaptic ...
Effect of gem-difluorination on the conformation of selected hydrocarbon systems
(University of St Andrews, 2014-06-25) - Thesis
Owing to its unique electronic properties, the CF₂ group has the potential to affect the conformation and polarity of molecules. The Introduction provides an overview of the conformational effects induced by the incorporation ...