Now showing items 1-6 of 6
Virulent and avirulent strains of Toxoplasma gondii which differ in their glycosylphosphatidylinositol content induce similar biological functions in macrophages
(2014-01-28) - Journal article
Glycosylphosphatidylinositols (GPIs) from several protozoan parasites are thought to elicit a detrimental stimulation of the host innate immune system aside their main function to anchor surface proteins. Here we analyzed ...
Plasmodium falciparum choline kinase inhibition leads to a major decrease in phosphatidylethanolamine causing parasite death
(2016-09-12) - Journal article
Malaria is a life-threatening disease caused by different species of the protozoan parasite Plasmodium, with P. falciparum being the deadliest. Increasing parasitic resistance to existing antimalarials makes the necessity ...
TrypanoCyc : a community-led biochemical pathways database for Trypanosoma brucei
(2015-01-28) - Journal article
The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions. Our ...
Regulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host
(2013-06-26) - Journal article
The gene expression of Trypanosoma brucei has been examined extensively in the blood of mammalian hosts and in forms found in the midgut of its arthropod vector, the tsetse fly. However, trypanosomes also undergo development ...
Lipidomic analysis of fats and oils – a lot more than just omega-3
(2015-01) - Journal article
Edible oils and fats are among the most abundant cooking ingredients in the world, and are an important part of a healthy balanced diet, especially if they are high in omega-6 and omega-3 polyunsaturated fatty acids. Rather ...
Blocking Variant Surface Glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation
(2009-10-26) - Journal article
Background: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian ...