Now showing items 1-10 of 12
Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase
(2016-03-21) - Journal article
The substrate scope of fluorinase enzyme mediated transhalogenation reactions is extended. Substrate tolerance allows a peptide cargo to be tethered to a 5'-chloro-5'-deoxynucleoside substrate for transhalogenation by the ...
Strategies for radiolabelling antibody, antibody fragments and affibodies with fluorine-18 as tracers for positron emission tomography (PET)
(2017-11) - Journal item
The use of fluorine-18 as a radionuclide for positron emission tomography (PET) has become increasingly popular over the last two decades and cancer and neurology clinical centres worldwide are increasingly establishing ...
Organo-fluorine chemistry II
(2010-04-20) - Journal item
Inter- and intramolecular CF···C=O interactions on aliphatic and cyclohexane carbonyl derivatives
(2015) - Journal article
The assessment of weak inter- and intra- molecular Cδ+Fδ-...Cδ+=Oδ- interactions were theoretically evaluated in 4 different sets of compounds at different theoretical levels. Intermolecular CH3F...C=O interactions were ...
Incorporation of [2H1]-(1R,2R)- and [2H1]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus
(2017-10-14) - Journal article
Deuterium incorporations from [2H1]-(1R,2R) and [2H1]-(1S,2R) glycerols into the fluorine containing antibiotic nucleocidin, in Streptomyces calvus indicate that one deuterium atom is incorporated at the C-5′ site of ...
Hyperconjugation is the source of helicity in perfluorinated n-alkanes
(2017-06-26) - Journal article
Hyperconjugative, steric and electrostatic effects were evaluated as possible sources of the helicity in linear perfluorinated alkanes through analysis of natural bond orbitals and classical electrostatics. Contrary to ...
Organo-fluorine chemistry III
(2013-10-23) - Journal item
A novel class of fluorinated A2A adenosine receptor agonist with application to last step enzymatic [18F]fluorination for PET imaging
(2017-11-02) - Journal article
The A2A adenosine receptor belongs to a family of G-coupled protein receptors that have been subjected to extensive investigation over the last few decades. Due to their prominent role in the biological functions of the ...
A localised tolerance in the substrate specificity of the fluorinase enzyme enables "last step" 18F fluorination of a RGD peptide under ambient aqueous conditions
(2014-08-18) - Journal article
A strategy for last-step 18F fluorination of bioconjugated peptides is reported that exploits an “Achilles heel” in the substrate specificity of the fluorinase enzyme. An acetylene functionality at the C-2 position of the ...
Bis(trifluoromethyl)methylene addition to vinyl-terminated SAMs : a gas-phase C–C bond-forming reaction on a surface
(2014-05-20) - Journal article
Vinyl-terminated self-assembled monolayers (SAMs) on silicon oxide substrates were chemically modified by the addition of a bis(trifluoromethyl)methylene group in a rare gas-phase C–C bond-forming reaction to directly ...