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dc.contributor.authorGialluisi, Alessandro
dc.contributor.authorAndlauer, Till F. M.
dc.contributor.authorMirza-schreiber, Nazanin
dc.contributor.authorMoll, Kristina
dc.contributor.authorBecker, Jessica
dc.contributor.authorHoffmann, Per
dc.contributor.authorLudwig, Kerstin U.
dc.contributor.authorCzamara, Darina
dc.contributor.authorSt Pourcain, Beate
dc.contributor.authorBrandler, William
dc.contributor.authorHonbolygó, Ferenc
dc.contributor.authorTóth, Dénes
dc.contributor.authorCsépe, Valéria
dc.contributor.authorHuguet, Guillaume
dc.contributor.authorMorris, Andrew P.
dc.contributor.authorHulslander, Jacqueline
dc.contributor.authorWillcutt, Erik G.
dc.contributor.authorDefries, John C.
dc.contributor.authorOlson, Richard K.
dc.contributor.authorSmith, Shelley D.
dc.contributor.authorPennington, Bruce F.
dc.contributor.authorVaessen, Anniek
dc.contributor.authorMaurer, Urs
dc.contributor.authorLyytinen, Heikki
dc.contributor.authorPeyrard-janvid, Myriam
dc.contributor.authorLeppänen, Paavo H. T.
dc.contributor.authorBrandeis, Daniel
dc.contributor.authorBonte, Milene
dc.contributor.authorStein, John F.
dc.contributor.authorTalcott, Joel B.
dc.contributor.authorFauchereau, Fabien
dc.contributor.authorWilcke, Arndt
dc.contributor.authorFrancks, Clyde
dc.contributor.authorBourgeron, Thomas
dc.contributor.authorMonaco, Anthony P.
dc.contributor.authorRamus, Franck
dc.contributor.authorLanderl, Karin
dc.contributor.authorKere, Juha
dc.contributor.authorScerri, Thomas S.
dc.contributor.authorParacchini, Silvia
dc.contributor.authorFisher, Simon E.
dc.contributor.authorSchumacher, Johannes
dc.contributor.authorNöthen, Markus M.
dc.contributor.authorMüller-myhsok, Bertram
dc.contributor.authorSchulte-körne, Gerd
dc.date.accessioned2019-02-12T13:30:04Z
dc.date.available2019-02-12T13:30:04Z
dc.date.issued2019-02-11
dc.identifier.citationGialluisi , A , Andlauer , T F M , Mirza-schreiber , N , Moll , K , Becker , J , Hoffmann , P , Ludwig , K U , Czamara , D , St Pourcain , B , Brandler , W , Honbolygó , F , Tóth , D , Csépe , V , Huguet , G , Morris , A P , Hulslander , J , Willcutt , E G , Defries , J C , Olson , R K , Smith , S D , Pennington , B F , Vaessen , A , Maurer , U , Lyytinen , H , Peyrard-janvid , M , Leppänen , P H T , Brandeis , D , Bonte , M , Stein , J F , Talcott , J B , Fauchereau , F , Wilcke , A , Francks , C , Bourgeron , T , Monaco , A P , Ramus , F , Landerl , K , Kere , J , Scerri , T S , Paracchini , S , Fisher , S E , Schumacher , J , Nöthen , M M , Müller-myhsok , B & Schulte-körne , G 2019 , ' Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia ' , Translational Psychiatry , vol. 9 , 77 . https://doi.org/10.1038/s41398-019-0402-0en
dc.identifier.issn2158-3188
dc.identifier.otherPURE: 257320527
dc.identifier.otherPURE UUID: d487cab7-bcaf-430d-97a1-0c917e53eb13
dc.identifier.othercrossref: 10.1038/s41398-019-0402-0
dc.identifier.othercrossref: 10.1038/s41398-019-0402-0
dc.identifier.otherScopus: 85061296237
dc.identifier.otherORCID: /0000-0001-9934-8602/work/60428095
dc.identifier.otherWOS: 000459834900001
dc.identifier.urihttp://hdl.handle.net/10023/17043
dc.descriptionA.G. and T.F.M.A. were supported by the Munich Cluster for Systems Neurology (SyNergy). S.P. is a Royal Society University research Fellow. B.M.M., C.F., B.S.P., and S.E.F. are supported by the Max Planck Society. A.P.M. is a Wellcome Senior Fellow in Basic Biomedical Science (WT098017). F.R. is supported by Agence Nationale de la Recherche (ANR-06-NEURO-019-01, ANR-10-LABX-0087 IEC, ANR-10-IDEX-0001-02 PSL, ANR-11-BSV4-014-01), European Commission (LSHM-CT-2005-018696), Ville de Paris.en
dc.description.abstractDevelopmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the largest studies available, including nine cohorts of reading-impaired and typically developing children of European ancestry (N = 2562–3468). We observed a genome-wide significant effect (p < 1 × 10−8) on rapid automatized naming of letters (RANlet) for variants on 18q12.2, within MIR924HG (micro-RNA 924 host gene; rs17663182 p = 4.73 × 10−9), and a suggestive association on 8q12.3 within NKAIN3 (encoding a cation transporter; rs16928927, p = 2.25 × 10−8). rs17663182 (18q12.2) also showed genome-wide significant multivariate associations with RAN measures (p = 1.15 × 10−8) and with all the cognitive traits tested (p = 3.07 × 10−8), suggesting (relational) pleiotropic effects of this variant. A polygenic risk score (PRS) analysis revealed significant genetic overlaps of some of the DD-related traits with educational attainment (EDUyears) and ADHD. Reading and spelling abilities were positively associated with EDUyears (p ~ [10−5–10−7]) and negatively associated with ADHD PRS (p ~ [10−8−10−17]). This corroborates a long-standing hypothesis on the partly shared genetic etiology of DD and ADHD, at the genome-wide level. Our findings suggest new candidate DD susceptibility genes and provide new insights into the genetics of dyslexia and its comorbities.
dc.format.extent15
dc.language.isoeng
dc.relation.ispartofTranslational Psychiatryen
dc.rightsCopyright © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectRJ Pediatricsen
dc.subjectQH301 Biologyen
dc.subjectDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject~DC~en
dc.subject.lccRC0321en
dc.subject.lccRJen
dc.subject.lccQH301en
dc.titleGenome-wide association scan identifies new variants associated with a cognitive predictor of dyslexiaen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Cellular Medicine Divisionen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.Centre for Biophotonicsen
dc.identifier.doihttps://doi.org/10.1038/s41398-019-0402-0
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.biorxiv.org/content/early/2018/05/02/309336en


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