Now showing items 1-10 of 24
Investigating the trypanocidal activity of simplified natural product-like analogs and the characterization of a novel trypanosomatid-specific secondary alternative oxidase
(University of St Andrews, 2017-12-07) - Thesis,
This thesis aimed to identify the trypanocidal mode of action of non-natural chamuvarinin analogs, and to assess the previously uncharacterized secondary alternative oxidase (AOX2) as a possible drug target of the ...
Lipids and liposomes in the enhancement of health and treatment of disease
(InTech, 2015-06-03) - Book item,
Regulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host
(2013-06-26) - Journal article,
The gene expression of Trypanosoma brucei has been examined extensively in the blood of mammalian hosts and in forms found in the midgut of its arthropod vector, the tsetse fly. However, trypanosomes also undergo development ...
TrypanoCyc : a community-led biochemical pathways database for Trypanosoma brucei
(2015-01-28) - Journal article,
The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions. Our ...
Lipidomic analysis of fats and oils – a lot more than just omega-3
(2015-01) - Journal article,
Edible oils and fats are among the most abundant cooking ingredients in the world, and are an important part of a healthy balanced diet, especially if they are high in omega-6 and omega-3 polyunsaturated fatty acids. Rather ...
Trypanosoma brucei bloodstream forms depend upon uptake of myo-inositol for Golgi phosphatidylinositol synthesis and normal cell growth
(2015-06) - Journal article,
myo-Inositol is a building block for all inositol-containing phospholipids in eukaryotes. It can be synthesized de novo from glucose-6-phosphate in the cytosol and endoplasmic reticulum. Alternatively, it can be taken up ...
Plasmodium falciparum choline kinase inhibition leads to a major decrease in phosphatidylethanolamine causing parasite death
(2016-09-12) - Journal article,
Malaria is a life-threatening disease caused by different species of the protozoan parasite Plasmodium, with P. falciparum being the deadliest. Increasing parasitic resistance to existing antimalarials makes the necessity ...
Sugar activation and glycosylation in Plasmodium
(2015-10-31) - Journal article,
Glycoconjugates are important mediators of host-pathogen interactions and are usually very abundant in the surface of many protozoan parasites. However, in the particular case of Plasmodium species, previous works show ...
A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro
(2013-02-14) - Journal article,
Recently, the World Health Organization approved the nifurtimox–eflornithine combination therapy for the treatment of human African trypanosomiasis, renewing interest in nitroheterocycle therapies for this and associated ...
The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei
(2014-05) - Journal article,
Lipid metabolism in Trypanosoma brucei, the causative agent of African sleeping sickness, differs from its human host in several fundamental ways. This has lead to the validation of a plethora of novel drug targets, giving ...