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  • Human IFNAR2 deficiency : lessons for antiviral immunity 

    Duncan, Christopher J. A.; Mohamad, Siti M. B.; Young, Dan Frushard; Skelton, Andrew J.; Leahy, T. Ronan; Munday, Diane Carolyn; Butler, Karina M.; Morfopoulou, Sofia; Brown, Julianne R.; Hubank, Mike; Connell, Jeff; Gavin, Patrick J.; McMahon, Cathy; Dempsey, Eugene; Lynch, Niamh E.; Jacques, Thomas S.; Valappil, Manoj; Cant, Andrew J.; Breuer, Judith; Engelhardt, Karin R.; Randall, Richard Edward; Hambleton, Sophie (2015-09-30) - Journal article
    Type I interferon (IFN-α/β) is a fundamental antiviral defense mechanism. Mouse models have been pivotal to understanding the role of IFN-α/β in immunity, although validation of these findings in humans has been limited. ...