Now showing items 1-2 of 2

    • A computational approach to discovering p53 binding sites in the human genome 

      Lim, Ji-Hyun (University of St Andrews, 2013-06) - Thesis
      The tumour suppressor p53 protein plays a central role in the DNA damage response/checkpoint pathways leading to DNA repair, cell cycle arrest, apoptosis and senescence. The activation of p53-mediated pathways is primarily ...
    • PRIMA-1Met suppresses colorectal cancer independent of p53 by targeting MEK 

      Lu, Tao; Zou, Yanmei; Xu, Guogang; Potter, Jane A.; Taylor, Garry L.; Duan, Qiuhong; Yang, Qin; Xiong, Huihua; Qiu, Hong; Ye, Dawei; Zhang, Peng; Yu, Shiying; Yuan, Xianglin; Zhu, Feng; Wang, Yihua; Xiong, Hua (2016-10-27) - Journal article
      PRIMA-1Met is the methylated PRIMA-1 (p53 reactivation and induction of massive apoptosis) and could restore tumor suppressor function of mutant p53 and induce p53 dependent apoptosis in cancer cells harboring mutant p53. ...