Now showing items 1-10 of 118
A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants
(2016-12-13) - Journal article,
Background : Cluster Headache (CH) is a severe primary headache, with a poorly understood pathophysiology. Complex genetic factors are likely to play a role in CH etiology; however, no confirmed gene associations have been ...
Association of human papillomavirus 16 E2 with Rad50-interacting protein 1 enhances viral DNA replication
(2017-03) - Journal article,
Rad50-interacting protein 1 (Rint1) associates with the DNA damage response protein Rad50 during the transition from the S phase to the G2/M phase and functions in radiation-induced G2 checkpoint control. It has also been ...
Cohort profile : the Scottish Research register SHARE. A register of people interested in research participation linked to NHS data sets
(2017-02-01) - Journal article,
Purpose : Recruitment to trials is often difficult. Many trials fail to meet recruitment targets resulting in underpowered studies which waste resources and the time of those who participated. While there is evidence that ...
Finding and using routine clinical datasets for observational research and quality improvement
(2018-03) - Journal article,
Lost revenues in low income countries
(2017-08-10) - Working or discussion paper,
This research estimates how much revenue six low income countries – of which five are in sub Saharan Africa - are losing unnecessarily from various potential revenue streams that could be used to fund public services. In ...
Heterogeneity mapping of protein expression in tumors using quantitative immunofluorescence
(2011-10-25) - Journal article,
Morphologic heterogeneity within an individual tumor is well-recognized by histopathologists in surgical practice. While this often takes the form of areas of distinct differentiation into recognized histological subtypes, ...
Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection
(2015-09) - Journal article,
Strangles, the most frequently diagnosed infectious disease of horses worldwide, is caused by Streptococcus equi. Despite its prevalence, the global diversity and mechanisms underlying the evolution of S. equi as a ...
Copy number variation screen identifies a rare de novo deletion at chromosome 15q13.1-13.3 in a child with language impairment
(2015-08-11) - Journal article,
A significant proportion of children (up to 7% in the UK) present with pronounced language difficulties that cannot be explained by obvious causes like other neurological and medical conditions. A substantial genetic ...
Complete genome sequence of MIDG2331, a genetically tractable serovar 8 clinical isolate of Actinobacillus pleuropneumoniae
(2016-01-28) - Journal article,
We report here the complete annotated genome sequence of a clinical serovar 8 isolate Actinobacillus pleuropneumoniae MIDG2331. Unlike the serovar 8 reference strain 405, MIDG2331 is amenable to genetic manipulation via ...
Improving health professionals’ communication skills : a major global endeavour
(2015-01) - Journal item,
Growth and the phenomenon of Mainland China Mainland China is a country where the statistics about human activity and volume of services are breathtaking. To give a sense of the staggering nature of the size of this rapid ...