Now showing items 1-10 of 85
Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high fat diet
(2017-12) - Journal article,
The aim of this study was to investigate whether the presence of endogenous estradiol alters the effects of a high-fat (HF) diet on activity/expression of the cardiac Na+/K+-ATPase, via PI3K/IRS and RhoA/ROCK signalling ...
Epigenetic sampling effects : nephrectomy modifies the clear cell renal cell cancer methylome
(2017-06) - Journal article,
Background: Sample collection for clinical epigenetics research often occurs at the time of surgical excision of a diseased organ. However, this approach may compromise the epigenetic profile under study. The use of different ...
2015 epidemic of severe Streptococcus agalactiae sequence type 283 infections in Singapore associated with the consumption of raw freshwater fish : a detailed analysis of clinical, epidemiological, and bacterial sequencing data
(2017-05-15) - Journal article,
Background : Streptococcus agalactiae (group B Streptococcus [GBS]) has not been described as a foodborne pathogen. However, in 2015, a large outbreak of severe invasive sequence type (ST) 283 GBS infections in adults ...
The genetic relationship between handedness and neurodevelopmental disorders
(2014-02) - Journal article,
Handedness and brain asymmetry have been linked to neurodevelopmental disorders such as dyslexia and schizophrenia. The genetic nature of this correlation is not understood. Recent discoveries have shown handedness is ...
The transcriptomes of Xiphinema index and Longidorus elongatus suggest independent acquisition of some plant parasitism genes by horizontal gene transfer in early-branching nematodes
(2017-10-23) - Journal article,
Nematodes have evolved the ability to parasitize plants on at least four independent occasions, with plant parasites present in Clades 1, 2, 10 and 12 of the phylum. In the case of Clades 10 and 12, horizontal gene transfer ...
Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice
(2017-07-20) - Journal article,
Background: The spread of drug-resistant bacterial pathogens poses a major threat to global health. It is widely recognised that the widespread use of antibiotics has generated selective pressures that have driven the ...
17ß-Estradiol protects against the effects of a high fat diet on cardiac glucose, lipid and nitric oxide metabolism in rats
(2017-05-05) - Journal article,
The aim of this study was to investigate the in vivo effects of estradiol (E2) on myocardial metabolism and inducible nitric oxide synthase (iNOS) expression/activity in obese rats. Male Wistar rats were fed with a normal ...
ST3268 : a geographically widespread primate MRSA clone
(2017-08-01) - Journal item,
Proposal of serovars 17 and 18 of Actinobacillus pleuropneumoniae based on serological and genotypic analysis
(2018-04) - Journal article,
The aim of this study was to investigate isolates of Actinobacillus pleuropneumoniae previously designated serologically either as NT or as ‘K2:07’, which did not produce serovar-specific amplicons in PCR assays. We used ...
Predicting the virulence of MRSA from its genome sequence
(2014-04-09) - Journal article,
Microbial virulence is a complex and often multifactorial phenotype, intricately linked to a pathogen's evolutionary trajectory. Toxicity, the ability to destroy host cell membranes, and adhesion, the ability to adhere to ...