St Andrews Research Repository

St Andrews University Home
View Item 
  •   St Andrews Research Repository
  • Biology (School of)
  • Biology
  • Biology Theses
  • View Item
  •   St Andrews Research Repository
  • Biology (School of)
  • Biology
  • Biology Theses
  • View Item
  •   St Andrews Research Repository
  • Biology (School of)
  • Biology
  • Biology Theses
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Plasma protein changes in open cardiac surgery

Thumbnail
View/Open
AllanLloydPhDThesis.pdf (43.22Mb)
Date
1970
Author
Lloyd, Allan Henry
Supervisor
Tristram, George Roland
Funder
Medical Research Council (MRC)
Metadata
Show full item record
Altmetrics Handle Statistics
Abstract
The literature on biochemical changes in open cardiac surgery with especial reference to plasma protein and amino acids has been reviewed. The changes that take place in plasma proteins during oxygenation of blood of open cardiac surgery have been investigated with emphasis on denaturation. This phenomena has been examined by the assay of blood and plasma sulfhydryl groups by different reagents and also viscosity and turbidity changes. The limitations of the two latter investigations has been discussed. Haemolytic changes in plasma have been examined and the related importance of sulfhydryl groups discussed. Plasma protein changes have been investigated by methods depending on net charge, shape, size, and molecular weight of individual molecules. Although adrenal cortical response to open cardiac surgery has been investigated it has been pertinent to reinvestigate adrenal cortical secretion pari passu with amino acid data from blood and urine samples of patients not only because of their metabolic associations, but also because of the opportunity of comparing surgical patients receiving supplementary haydrocortisone throughout open cardiac surgery with those not supplemented - the latter therefore depending on their own intrinsic secretion during surgical stress. A review of relevant literature has accordingly been presented with emphasis on the difficulties involved in ACTH assay of plasma from surgical patients, and the practical advantages of 17-hydroxycorticostereid assay in lieu of ACTH assays. The plasma and urinary amino acid increase have been examined together in detail comparing not only the increase in each amino acid at each operation but also comparing the increase of an amino acid in all the operations investigated thus obtaining mean values of each amino acid at regular intervals of time throughout each perfusion.
Type
Thesis, PhD Doctor of Philosophy
Collections
  • Biology Theses
URI
http://hdl.handle.net/10023/14906

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Advanced Search

Browse

All of RepositoryCommunities & CollectionsBy Issue DateNamesTitlesSubjectsClassificationTypeFunderThis CollectionBy Issue DateNamesTitlesSubjectsClassificationTypeFunder

My Account

Login

Open Access

To find out how you can benefit from open access to research, see our library web pages and Open Access blog. For open access help contact: openaccess@st-andrews.ac.uk.

Accessibility

Read our Accessibility statement.

How to submit research papers

The full text of research papers can be submitted to the repository via Pure, the University's research information system. For help see our guide: How to deposit in Pure.

Electronic thesis deposit

Help with deposit.

Repository help

For repository help contact: Digital-Repository@st-andrews.ac.uk.

Give Feedback

Cookie policy

This site may use cookies. Please see Terms and Conditions.

Usage statistics

COUNTER-compliant statistics on downloads from the repository are available from the IRUS-UK Service. Contact us for information.

© University of St Andrews Library

University of St Andrews is a charity registered in Scotland, No SC013532.

  • Facebook
  • Twitter