Now showing items 1-4 of 4

    • Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors 

      Florence, Gordon J.; Fraser, Andrew L.; Gould, Eoin R.; King, Elizabeth F. B.; Menzies, Stefanie K.; Morris, Joanne C.; Tulloch, Lindsay B.; Smith, Terry K. (2014-11) - Journal article
      Neglected tropical diseases remain a serious global health concern. Here, a series of novel bis-tetrahydropyran 1,4-triazole analogues based on the framework of chamuvarinin, a polyketide natural product isolated from the ...
    • Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis 

      Healy, Alan; Izumikawa, Miho; Slawin, Alexandra Martha Zoya; Shin-ya, Kazuo; Westwood, Nicholas James (2015-03-23) - Journal article
      Recent reports have highlighted the biological activity associated with a sub-family of the tetramic acid class of natural products. Despite the fact that members of this sub-family act as protein-protein interaction ...
    • Stereospecific dehydroxyfluorination and the synthesis of trifluoro D-hexose sugar analogues 

      Bresciani, Stefano (University of St Andrews, 2011-06-22) - Thesis
      This thesis describes stereospecific fluorination reactions, and addresses the synthesis of fluorosugars. In Chapter 1, the influence of fluorine on the physical properties of organic molecules, as well as its stereoelectronic ...
    • The total synthesis of chamuvarinin 

      Morris, Joanne Charleen (University of St Andrews, 2013-11-29) - Thesis
      In 2004, the polyketide natural product, chamuvarinin (72) was isolated by Laurens et al. from the roots of Uvaria chamae, a member of the Annonaceae plant family. This unique tetrahydropyran containing acetogenin displayed ...