Now showing items 1-5 of 5

    • Allosteric modulation of Beta1 Integrin function induces lung tissue repair 

      Aljamal-naylor, Rehab; Wilson, Linda; Mcintyre, Susan; Rossi, Fiona; Harrison, Beth; Marsden, Mark; Harrison, David J. (2012) - Journal article
      The cellular cytoskeleton, adhesion receptors, extracellular matrix composition, and their spatial distribution are together fundamental in a cell's balanced mechanical sensing of its environment. We show that, in lung ...
    • Crambled : a Shiny application to enable intuitive resolution of conflicting cellularity estimates 

      Lynch, Andy (2015-12-07) - Journal article
      It is now commonplace to investigate tumour samples using whole-genome sequencing, and some commonly performed tasks are the estimation of cellularity (or sample purity), the genome-wide profiling of copy numbers, and the ...
    • Decomposition of mutational context signatures using quadratic programming methods 

      Lynch, Andy G. (2016-06-07) - Journal article
      Methods for inferring signatures of mutational contexts from large cancer sequencing data sets are invaluable for biological research, but impractical for clinical application where we require tools that decompose the ...
    • The role of delamanid in the treatment of drug-resistant tuberculosis 

      Lewis, Joseph M.; Sloan, Derek James (2015-05-13) - Journal item
      Tuberculosis (TB) remains a significant cause of death worldwide, and emergence of drug-resistant TB requires lengthy treatments with toxic drugs that are less effective than their first-line equivalents. New treatments ...
    • Whole-genome sequencing of nine esophageal adenocarcinoma cell lines 

      Contino, Gianmarco; Eldridge, Matthew D.; Secrier, Maria; Bower, Lawrence; Elliott, Rachael Fels; Weaver, Jamie; Lynch, Andy G.; Edwards, Paul A.W.; Fitzgerald, Rebecca C. (2016-06-10) - Journal article
      Esophageal adenocarcinoma (EAC) is highly mutated and molecularly heterogeneous. The number of cell lines available for study is limited and their genome has been only partially characterized. The availability of an accurate ...