Now showing items 1-7 of 7

    • Copper(I)-N-heterocyclic carbene (NHC) complexes : synthesis, characterisation and applications in synthesis and catalysis 

      Santoro, Orlando (University of St Andrews, 2016) - Thesis
      The work described herein focuses on the synthesis and characterisation of copper(I) complexes bearing N-heterocyclic carbene (NHC) ligands, their use in catalysis as well as organometallic synthesis and related reaction ...
    • Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer 

      Stewart, Grant D.; Powles, Thomas; Van Neste, Christophe; Meynert, Alison; O'Mahony, Fiach; Laird, Alexander; Deforce, Dieter; Van Nieuwerburgh, Filip; Trooskens, Geert; Van Criekinge, Wim; De Meyer, Tim; Harrison, David James (2016-03-23) - Journal article
      Background: Genetic intratumoral heterogeneity (ITH) hinders biomarker development in metastatic clear cell renal cancer (mccRCC). Epigenetic relative to genetic ITH or the presence of consistent epigenetic changes following ...
    • Epigenetic sampling effects : nephrectomy modifies the clear cell renal cell cancer methylome 

      Van Neste, Christophe; Laird, Alexander; O'Mahony, Fiach; Van Criekinge, Wim; Deforce, Dieter; Van Nieuwerbugh, Filip; Powles, Thomas; Harrison, David James; Stewart, Grant D.; De Meyer, Tim (2017-06) - Journal article
      Background: Sample collection for clinical epigenetics research often occurs at the time of surgical excision of a diseased organ. However, this approach may compromise the epigenetic profile under study. The use of different ...
    • Genetic and epigenetic analyses of MBD3 in colon and lung cancer 

      Zhu, Y; Harrison, D J; Bader, S A (2004-05-17) - Journal article
      MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our ...
    • HES5 silencing is an early and recurrent change in prostate tumourigenesis 

      Massie, Charles E.; Spiteri, Inmaculada; Ross-Adams, Helen; Luxton, Hayley; Kay, Jonathan; Whitaker, Hayley C.; Dunning, Mark J.; Lamb, Alastair D.; Ramos-Montoya, Antonio; Brewer, Daniel S.; Cooper, Colin S.; Eeles, Rosalind; Warren, Anne Y.; Tavaré, Simon; Neal, David E.; Lynch, Andy G.; UK Prostate ICGC Group (2015-04-01) - Journal article
      Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent ...
    • The importance of DNA methylation in prostate cancer development 

      Massie, Charles E.; Mills, Ian G.; Lynch, Andy G. (2017-02) - Journal item
      After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific ...
    • Structure of the CRISPR Interference complex CSM reveals key similarities with Cascade 

      Rouillon, Christophe; Zhou, Min; Zhang, Jing; Argyris, Politis; Beilsten-Edmands, Victoria; Cannone, Guiseppe; Graham, Shirley; Robinson, Carol; Spagnolo, Laura; White, Malcolm F (2013-10-10) - Journal article
      The Clustered Regularly Interspaced Palindromic Repeats (CRISPR) system is an adaptive immune system in prokaryotes. Interference complexes encoded by CRISPR-associated (cas) genes utilize small RNAs for homology-directed ...