Now showing items 1-11 of 11

    • Blood, sex and trust: : The limits of the population-based risk management paradigm 

      Kesby, Mike; Sothern, Matthew Barry (2014-03) - Journal article
      Blood screening is imperfect so Donor Health Check questionnaires (DHC) are used to defer those whose ‘behaviour’ suggests disproportionate risk of Blood Borne Infection (BBI). Taking the UK case, we compare deferment of ...
    • Challenges in the management of HIV-infected malnourished children in Sub-Saharan Africa 

      Trehan, I.; O'Hare, Bernadette Ann-Marie; Phiri, A.; Heikens, G.T. (2012-01-01) - Journal article
      Infection with HIV, and oftentimes coinfection with TB, complicates the care of severely malnourished children in sub-Saharan Africa. These superimposed infections challenge clinicians faced with a population of malnourished ...
    • Clinical characteristics and lung function in older children vertically infected with Human Immunodeficiency Virus in Malawi 

      Mwalukomo, Thandie; Rylance, Sarah; Webb, Emily; Anderson, Suzanne; O'Hare, Bernadette Ann-Marie; van Oosterhout, Joep J.; Ferrand, Rashida A.; Corbett, Elizabeth L.; Rylance, Jamie (2016-06) - Journal article
      Background Antiretroviral therapy (ART) has led to increased survival of children with vertically acquired human immunodeficiency virus infection. Significant morbidity arises from respiratory symptoms, but aetiology and ...
    • Cryptococcal meningitis : epidemiology and therapeutic options 

      Sloan, Derek J.; Parris, Victoria (2014-05-13) - Journal item
      Cryptococcal meningitis causes morbidity and mortality worldwide. The burden of disease is greatest in middle- and low-income countries with a high incidence of human immunodeficiency virus (HIV infection. Patients taking ...
    • Early use of corticosteroids in infants with a clinical diagnosis of Pneumocystis jiroveci pneumonia in Malawi : a double blinded, randomised clinical trial 

      Newberry, Laura; O'Hare, Bernadette; Kennedy, Neil; Selman, Andrew; Omar, Sofia; Dawson, Pamela; Stevenson, Kim; Nishihara, Yo; Lissauer, Samantha; Molyneux, Elizabeth (2017) - Journal article
      Background: Pneumocystis jiroveci pneumonia (PJP) is the most common opportunistic infection in infants with vertically acquired HIV infection and the most common cause ofdeath in HIV-infected infants. Objectives: To ...
    • Evidence of improving antiretroviral therapy treatment delays : an analysis of eight years of programmatic outcomes in Blantyre, Malawi 

      Sloan, Derek J.; Van Oosterhout, Joep J.; Malisita, Ken; Phiri, Eddie M.; Lalloo, David G.; O'Hare, Bernadette; MacPherson, Peter (2013-05-21) - Journal article
      AbstractBackground: Impressive achievements have been made towards achieving universal coverage of antiretroviral therapy (ART) in sub-Saharan Africa. However, the effects of rapid ART scale-up on delays between HIV ...
    • HIV coinfection influences the inflammatory response but not the outcome of cerebral malaria in Malawian children 

      Mbale, Emmie W.; Moxon, Christopher A.; Mukaka, Mavuto; Chagomerana, Maganizo; Glover, Simon; Chisala, Ngawina; Omar, Sofia; Molyneux, Malcolm; Seydel, Karl; Craig, Alister G.; Taylor, Terrie; Heyderman, Robert S.; Mallewa, Macpherson (2016-09) - Journal article
      Objectives. Study of the effect of HIV on disease progression in heterogeneous severe malaria syndromes with imprecise diagnostic criteria has led to varying results. Characteristic retinopathy refines cerebral malaria ...
    • Late presentation with HIV in Africa : phenotypes, risk, and risk stratification in the REALITY trial 

      Siika, Abraham; McCabe, Leanne; Bwakura-Dangarembizi, Mutsa; Kityo, Cissy; Mallewa, Jane; Berkley, Jay; Maitland, Kath; Griffiths, Anna; Baleeta, Keith; Mudzingwa, Shepherd; Abach, James; Nathoo, Kusum; Thomason, Margaret J.; Prendergast, Andrew J.; Walker, Ann Sarah; Gibb, Diana M.; Mugyenyi, P.; Kityo, C.; Musiime, V.; Wavamunno, P.; Nambi, E.; Ocitti, P.; Ndigendawani, M.; Kemigisa, M.; Acen, J.; Olebo, D.; Mpamize, G.; Amone, A.; Okweny, D.; Mbonye, A.; Nambaziira, F.; Rweyora, A.; Kangah, M.; Kabaswahili, V.; Abach, J.; Abongomera, G.; Omongin, J.; Aciro, I.; Philliam, A.; Arach, B.; Ocung, E.; Amone, G.; Miles, P.; Adong, C.; Tumsuiime, C.; Kidega, P.; Otto, B.; Apio, F.; Baleeta, K.; O'Hare, B. (2018-04-01) - Journal article
      Background. Severely immunocompromised human immunodefciency virus (HIV)-infected individuals have high mortality shortly afer starting antiretroviral therapy (ART). We investigated predictors of early mortality and "late ...
    • Protease mediated maturation of HIV: Inhibitors of protease and the maturation process 

      Adamson, Catherine S (2012) - Journal item
      Protease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially ...
    • Systems medicine and infection 

      Bowness, Ruth (Springer, 2016) - Book item
      By using a systems based approach, mathematical and computational techniques can be used to develop models that describe the important mechanisms involved in infectious diseases. An iterative approach to model development ...
    • Vitamin D deficiency in Malawian adults with pulmonary tuberculosis : risk factors and treatment outcomes 

      Sloan, Derek James; Mwandumba, H. C.; Kamdolozi, M.; Shani, D.; Chisale, B.; Dutton, J.; Khoo, S. H.; Allain, T. J.; Davies, G. R. (2015-08-01) - Journal article
      SETTING: Vitamin D deficiency is common in African adults with tuberculosis (TB), and may be exacerbated by the metabolic effects of anti-tuberculosis drugs and antiretroviral therapy (ART). It is unclear whether vitamin ...