Now showing items 1-3 of 3

    • cis-Cyclopropylamines as mechanism-based inhibitors of Monoamine Oxidases 

      Malcomson, Thomas; Kelekci, Kemal; Borrello, Maria T.; Ganesan, A.; Semina, Elena; De Kimpe, Norbert; Mangelinckx, Sven; Ramsay, Rona R. (2015-08) - Journal article
      Cyclopropylamines, inhibitors of monoamine oxidases (MAO) and lysine-specific demethylase (LSD1), provide a useful structural scaffold for the design of mechanism-based inhibitors for the therapy of depression and cancer. ...
    • Computational studies of biomolecules 

      Chen, Sih-Yu (University of St Andrews, 2017-06-21) - Thesis
      In modern drug discovery, lead discovery is a term used to describe the overall process from hit discovery to lead optimisation, with the goal being to identify drug candidates. This can be greatly facilitated by the use ...
    • Drug design for CNS diseases: polypharmacological profiling of compounds using cheminformatic, 3D-QSAR and virtual screening methodologies 

      Nikolic, Katarina; Mavridis, Lazaros; Djikic, Teodora; Vukicevic, Jelica; Agbaba, Danica; Yelekci, Kemel; Mitchell, John B. O. (2016-06-10) - Journal article
      The diverse cerebral mechanisms implicated in CNS (Central Nervous System) diseases together with the heterogeneous and overlapping nature of phenotypes indicated that multitarget strategies may be appropriate for the ...