Now showing items 31-50 of 107

  • Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6 

    MacCallum, Stephanie F.; Groves, Michael J.; James, John; Murray, Karen; Appleyard, Virginia; Prescott, Alan R.; Drbal, Abed A.; Nicolaou, Anna; Cunningham, Joan; Haydock, Sally; Ganley, Ian G.; Westwood, Nicholas J.; Coates, Philip J.; Lain, Sonia; Tauro, Sudhir (2013-02-14) - Journal article
    Tenovin-6 (Tnv-6) is a bioactive small molecule with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-apoptotic effects of Tnv-6 ...
  • Electrical conductivity measurement in Thiel-embalmed tissue model : relevance to radiofrequency ablation 

    Wang, Z.; Luo, H.; Nick, M.; Gueorguieva, M.; Andre, P.; Baker, R.T.; McLean, D.; Brown, S.; Cuschieri, A. (2014-07-31) - Journal article
    Thiel-embalmed human cadaveric specimens are used widely for biomedical scientific investigation. This Letter reports electrical impedance measurements of Thiel-embalming solutions from 1 Hz to 32 MHz. Compared with other ...
  • Emergence of a new highly successful acapsular Group A Streptococcus clade of the genotype emm89 in the United Kingdom 

    Turner, Claire E.; Abbott, James; Lamagni, Theresa; Holden, Matthew; David, Sophia; Jones, Michael D.; Game, Laurence; Efstratiou, Androulla; Sriskandan, Shiranee (2015-07) - Journal article
    Group A Streptococcus (GAS) genotype emm89 is increasingly recognized as a leading cause of disease worldwide, yet factors that underlie the success of this emm-type are unknown. Surveillance identified a sustained nationwide ...
  • Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast 

    Bellamy, C O; Harrison, D J (1994-01) - Journal article
    Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 ...
  • Evidence for the continued use of medieval medical prescriptions in the sixteenth century : a fifteenth-century remedy book and its later owner 

    Connolly, Margaret (2016-04) - Journal article
    This article examines a fifteenth-century remedy book, Oxford, Bodleian Library, Rawlinson c. 299, and describes its collection of 314 medieval medical prescriptions. The recipes are organised broadly from head to toe, and ...
  • Evolutionary trade-offs underlie the multi-faceted virulence of Staphylococcus aureus 

    Laabei, Maisem; Uhlemann, Anne-Catrin; Lowy, Franklin D; Austin, Eloise D; Yokoyama, Maho; Ouadi, Khadija; Feil, Edward; Thorpe, Harry A; Williams, Barnabas; Perkins, Mark; Peacock, Sharon J; Clarke, Stephen R; Dordel, Janina; Holden, Matthew; Votintseva, Antonina A; Bowden, Rory; Crook, Derrick W; Young, Bernadette C; Wilson, Daniel J; Recker, Mario; Massey, Ruth C (2015-09-02) - Journal article
    Bacterial virulence is a multifaceted trait where the interactions between pathogen and host factors affect the severity and outcome of the infection. Toxin secretion is central to the biology of many bacterial pathogens ...
  • An externally validated age-related model of mean follicle density in the cortex of the human ovary 

    McLaughlin, Marie; Kelsey, Tom; Wallace, W Hamish B; Anderson, Richard A; Telfer, Evelyn E (2015-06) - Journal article
    The population of non-growing follicles present in the ovary is defined as the ovarian reserve. This underpins the reproductive lifespan in women, with its depletion determining age at loss of fertility and the menopause. ...
  • Fertility and parenthood issues in young female cancer patients - a systematic review 

    Sobota, Aleksandra; Ozakinci, Gozde (2014-12) - Journal article
    Purpose: For young women who were diagnosed with cancer prior to having children, reproductive potential might affect quality of life (QoL). This systematic review looks at fertility issues in young female cancer patients, ...
  • FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6 

    Galfre, Elena; Pitt, Samantha Jane; Venturi, Elisa; Sitsapesan, Mano; Zaccai, Nathan R; Tsaneva-Atanasova, Krasimira; O'Neill, Stephen; Sitsapesan, Rebecca (2012-02-21) - Journal article
    Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca2+-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel ...
  • Fruit, vegetable and dietary carotenoid intakes explain variation in skin-color in young caucasian women : a cross-sectional study 

    Pezdirc, Kristine; Hutchesson, Melinda J.; Whitehead, Ross; Ozakinci, Gozde; Perrett, David; Collins, Clare E. (2015-07-15) - Journal article
    Fruit and vegetables contain carotenoid pigments, which accumulate in human skin, contributing to its yellowness. This effect has a beneficial impact on appearance. The aim was to evaluate associations between diet (fruit, ...
  • General practitioners’ patient-centredness and responses to patients’ emotional cues and concerns : relationships with perceived empathy in areas of high and low socioeconomic deprivation 

    Lundy, Jenna-Marie; Bikker, Annemieke; Higgins, Maria; Watt, Graham C; Little, Paul; Humphris, Gerald Michael; Mercer, Stewart W (2015-03-17) - Journal article
    Background: Physician empathy is important to patients across the socio-economic spectrum. However, whether socioeconomic status (SES) influences how patients’ judge physician empathy is not known. We investigated how ...
  • Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort 

    Becker, Jessica; Czamara, Darina; Scerri, Tom S; Ramus, Franck; Csépe, Valéria; Talcott, Joel B; Stein, John; Morris, Andrew; Ludwig, Kerstin U; Hoffmann, Per; Honbolygó, Ferenc; Tóth, Dénes; Fauchereau, Fabien; Bogliotti, Caroline; Iannuzzi, Stéphanie; Chaix, Yves; Valdois, Sylviane; Billard, Catherine; George, Florence; Soares-Boucaud, Isabelle; Gérard, Christophe-Loïc; van der Mark, Sanne; Schulz, Enrico; Vaessen, Anniek; Maurer, Urs; Lohvansuu, Kaisa; Lyytinen, Heikki; Zucchelli, Marco; Brandeis, Daniel; Blomert, Leo; Leppänen, Paavo Ht; Bruder, Jennifer; Monaco, Anthony P; Müller-Myhsok, Bertram; Kere, Juha; Landerl, Karin; Nöthen, Markus M; Schulte-Körne, Gerd; Paracchini, Silvia; Peyrard-Janvid, Myriam; Schumacher, Johannes (2013-09-11) - Journal article
    Dyslexia is one of the most common childhood disorders with a prevalence of around 5-10% in school-age children. Although an important genetic component is known to have a role in the aetiology of dyslexia, we are far from ...
  • Genetic and epigenetic analyses of MBD3 in colon and lung cancer 

    Zhu, Y; Harrison, D J; Bader, S A (2004-05-17) - Journal article
    MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our ...
  • Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection 

    Harris, Simon R; Robinson, Carl; Steward, Karen F; Webb, Katy S; Paillot, Romain; Parkhill, Julian; Holden, Matthew T G; Waller, Andrew S (2015-09) - Journal article
    Strangles, the most frequently diagnosed infectious disease of horses worldwide, is caused by Streptococcus equi. Despite its prevalence, the global diversity and mechanisms underlying the evolution of S. equi as a ...
  • Genomic investigations unmask Mycoplasma amphoriforme, a new respiratory pathogen 

    Gillespie, Stephen H; Ling, Clare L; Oravcova, Katarina; Pinheiro, Miguel; Wells, Louise; Bryant, Josephine M; McHugh, Timothy D; Bébéar, Cecile; Webster, David; Harris, Simon R; Seth-Smith, Helena M B; Thomson, Nicholas R (2015-02-01) - Journal article
    Background. Mycoplasma amphoriforme has been associated with infection in patients with Primary Antibody Deficiency (PAD). Little is known about the natural history of infection with this organism and its ability to be ...
  • Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis 

    Weinert, Lucy A; Chaudhuri, Roy R; Wang, Jinhong; Peters, Sarah E; Corander, Jukka; Jombart, Thibaut; Baig, Abiyad; Howell, Kate J; Vehkala, Minna; Välimäki, Niko; Harris, David; Chieu, Tran Thi Bich; Van Vinh Chau, Nguyen; Campbell, James; Schultsz, Constance; Parkhill, Julian; Bentley, Stephen D; Langford, Paul R; Rycroft, Andrew N; Wren, Brendan W; Farrar, Jeremy; Baker, Stephen; Hoa, Ngo Thi; Holden, Matthew T G; Tucker, Alexander W; Maskell, Duncan J; BRaDP1T Consortium (2015-05) - Journal article
    Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S. suis, we study the genomes of 375 isolates ...
  • Genotypic diversity is associated with clinical outcome and phenotype in cryptococcal meningitis across Southern Africa 

    Beale, Mathew A; Sabiiti, Wilber; Robertson, Emma J; Fuentes-Cabrejo, Karen M; O'Hanlon, Simon J; Jarvis, Joseph N; Loyse, Angela; Meintjes, Graeme; Harrison, Thomas S; May, Robin C; Fisher, Matthew C; Bicanic, Tihana (2015-06-25) - Journal article
    Cryptococcal meningitis is a major cause of mortality throughout the developing world, yet little is known about the genetic markers underlying Cryptococcal virulence and patient outcome. We studied a cohort of 230 ...
  • The health and well-being of people with a previous diagnosis of cancer : a record-linkage study in Scotland 

    Evans, J.M.M.; Atherton, I.A.; Dibben, C.; Hubbard, G. (2011-10-30) - Journal article
    Routinely collected health care data (the Scottish Cancer Registry) were record-linked to representative survey data on health and health behaviours (the Government-funded Scottish Health Survey) to compare the health and ...
  • Heterogeneity mapping of protein expression in tumors using quantitative immunofluorescence 

    Faratian, Dana; Christiansen, Jason; Gustavson, Mark; Jones, Christine; Scott, Christopher; Um, InHwa; Harrison, David J (2011-10-25) - Journal article
    Morphologic heterogeneity within an individual tumor is well-recognized by histopathologists in surgical practice. While this often takes the form of areas of distinct differentiation into recognized histological subtypes, ...
  • How do medical students respond to emotional cues and concerns expressed by simulated patients during OSCE consultations? - A multilevel study 

    Zhou, Yuefang; Collinson, Alex; Laidlaw, Anita Helen; Humphris, Gerald Michael (2013-10-23) - Journal article
    Objectives: How medical students handle negative emotions expressed by simulated patients during Objective Structured Clinical Examinations (OSCE) has not been fully investigated. We aim to explore (i) whether medical ...