Now showing items 38-57 of 126

  • Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis 

    Ward, Philip N.; Holden, Matthew T. G.; Leigh, James A.; Lennard, Nicola; Bignell, Alexandra; Barron, Andy; Clark, Louise; Quail, Michael A.; Woodward, John; Barrell, Bart G.; Egan, Sharon A.; Field, Terence R.; Maskell, Duncan; Kehoe, Michael; Dowson, Christopher G.; Chanter, Neil; Whatmore, Adrian M.; Bentley, Stephen D.; Parkhill, Julian (2009-01-28) - Journal item
    Background: Streptococcus uberis, a Gram positive bacterial pathogen responsible for a significant proportion of bovine mastitis in commercial dairy herds, colonises multiple body sites of the cow including the gut, genital ...
  • Evolution of a complex locus : exon gain, loss and divergence at the Gr39a locus in Drosophila 

    Gardiner, Anastasia; Barker, Daniel; Butlin, Roger K.; Jordan, William C.; Ritchie, Michael G. (2008-01-30) - Journal article
    Background. Gene families typically evolve by gene duplication followed by the adoption of new or altered gene functions. A different way to evolve new but related functions is alternative splicing of existing exons of a ...
  • Evolution of homeobox gene clusters in animals : the Giga-cluster and primary versus secondary clustering 

    Ferrier, David Ellard Keith (2016-04-14) - Journal item
    The Hox gene cluster has been a major focus in evolutionary developmental biology. This is because of its key role in patterning animal development and widespread examples of changes in Hox genes being linked to the evolution ...
  • Evolution of the multifaceted eukaryotic akirin gene family 

    Macqueen, Daniel J.; Johnston, Ian A. (2009-02-06) - Journal article
    Background: Akirins are nuclear proteins that form part of an innate immune response pathway conserved in Drosophila and mice. This studies aim was to characterise the evolution of akirin gene structure and protein function ...
  • Expression of heat shock protein (Hsp90) paralogues is regulated by amino acids in skeletal muscle of Atlantic salmon 

    Garcia de la Serrana Castillo, Daniel; Johnston, Ian Alistair (2013-09-06) - Journal article
    Heat shock proteins 90 (Hsp90) have an essential role in sarcomere formation and differentiation in skeletal muscle and also act as molecular chaperones during protein folding impacting a wide range of physiological ...
  • Fast skeletal muscle transcriptome of the Gilthead sea bream (Sparus aurata) determined by next generation sequencing 

    Garcia de la Serrana Castillo, Daniel; Estevez, Alicia; Andree, Karl; Johnston, Ian Alistair (2012-05-11) - Journal article
    Background: The gilthead sea bream (Sparus aurata L.) occurs around the Mediterranean and along Eastern Atlantic coasts from Great Britain to Senegal. It is tolerant of a wide range of temperatures and salinities and is ...
  • FGFRL1 is a neglected putative actor of the FGF signalling pathway present in all major metazoan phyla 

    Bertrand, Stephanie; Somorjai, Ildiko; Garcia-Fernandez, Jordi; Lamonerie, Thomas; Escriva, Hector (2009-09-09) - Journal article
    Background: Fibroblast Growth Factors (FGF) and their receptors are well known for having major implications in cell signalling controlling embryonic development. Recently, a gene coding for a protein closely related to ...
  • Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis 

    Garcia, JS; Baranovskiy, AG; Knatko, EV; Gray, FC; Tahirov, TH; MacNeill, Stuart Andrew (2009-08-17) - Journal article
    Background: DNA polymerase delta plays an essential role in chromosomal DNA replication in eukaryotic cells, being responsible for synthesising the bulk of the lagging strand. In fission yeast, Pol delta is a heterotetrameric ...
  • Gene expression changes in diapause or quiescent potato cyst nematode, Globodera pallida, eggs after hydration or exposure to tomato root diffusate 

    Palomares-Rius, Juan Emilio; Hedley, Pete; Cock, Peter J A; Morris, Jenny A.; Jones, John T.; Blok, Vivian C. (2016-02-04) - Journal article
    Plant-parasitic nematodes (PPN) need to be adapted to survive in the absence of a suitable host or in hostile environmental conditions. Various forms of developmental arrest including hatching inhibition and dauer stages ...
  • Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability 

    Smith, Blair H.; Campbell, Harry; Blackwood, Douglas; Connell, John; Connor, Mike; Deary, Ian J.; Dominiczak, Anna F.; Fitzpatrick, Bridie; Ford, Ian; Jackson, Catherine Miriam; Haddow, Gillian; Kerr, Shona; Lindsay, Robert; McGilchrist, Mark; Morton, Robin; Murray, Graeme; Palmer, Colin N. A.; Pell, Jill P.; Ralston, Stuart H.; St Clair, David; Sullivan, Frank; Watt, Graham; Wolf, Roland; Wright, Alan; Porteous, David; Morris, Andrew D. (2006-10-02) - Journal article
    Background: Generation Scotland: the Scottish Family Health Study aims to identify genetic variants accounting for variation in levels of quantitative traits underlying the major common complex diseases (such as cardiovascular ...
  • Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort 

    Becker, Jessica; Czamara, Darina; Scerri, Tom S; Ramus, Franck; Csépe, Valéria; Talcott, Joel B; Stein, John; Morris, Andrew; Ludwig, Kerstin U; Hoffmann, Per; Honbolygó, Ferenc; Tóth, Dénes; Fauchereau, Fabien; Bogliotti, Caroline; Iannuzzi, Stéphanie; Chaix, Yves; Valdois, Sylviane; Billard, Catherine; George, Florence; Soares-Boucaud, Isabelle; Gérard, Christophe-Loïc; van der Mark, Sanne; Schulz, Enrico; Vaessen, Anniek; Maurer, Urs; Lohvansuu, Kaisa; Lyytinen, Heikki; Zucchelli, Marco; Brandeis, Daniel; Blomert, Leo; Leppänen, Paavo Ht; Bruder, Jennifer; Monaco, Anthony P; Müller-Myhsok, Bertram; Kere, Juha; Landerl, Karin; Nöthen, Markus M; Schulte-Körne, Gerd; Paracchini, Silvia; Peyrard-Janvid, Myriam; Schumacher, Johannes (2013-09-11) - Journal article
    Dyslexia is one of the most common childhood disorders with a prevalence of around 5-10% in school-age children. Although an important genetic component is known to have a role in the aetiology of dyslexia, we are far from ...
  • Genetic and morphometric evidence for parallel evolution of the Globigerinella calida morphotype 

    Weiner, A.K.M.; Weinkauf, M.F.G.; Kurasawa, A.; Darling, K.F.; Kucera, M. (2015-01) - Journal article
    Molecular genetic investigations of the highly abundant extant planktonic foraminifera plexus Globigerinella siphonifera/. Globigerinella calida have recently shown this group to be the genetically most diverse one within ...
  • The genetic relationship between handedness and neurodevelopmental disorders 

    Brandler, William M.; Paracchini, Silvia (2014-02) - Journal article
    Handedness and brain asymmetry have been linked to neurodevelopmental disorders such as dyslexia and schizophrenia. The genetic nature of this correlation is not understood. Recent discoveries have shown handedness is ...
  • Genome scan methods against more complex models : when and how much should we trust them? 

    de Villemereuil, Pierre; Frichot, Eric; Bazin, Eric; Francois, Olivier; Gaggiotti, Oscar E. (2014-04) - Journal article
    The recent availability of next-generation sequencing (NGS) has made possible the use of dense genetic markers to identify regions of the genome that may be under the influence of selection. Several statistical methods ...
  • The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay 

    Hjerde, Erik; Lorentzen, Marit Sjo; Holden, Matthew T. G.; Seeger, Kathy; Paulsen, Steinar; Bason, Nathalie; Churcher, Carol; Harris, David; Norbertczak, Halina; Quail, Michael A.; Sanders, Suzanne; Thurston, Scott; Parkhill, Julian; Willassen, Nils Peder; Thomson, Nicholas R. (2008-12-19) - Journal article
    Background: The fish pathogen Aliivibrio salmonicida is the causative agent of cold-water vibriosis in marine aquaculture. The Gram-negative bacterium causes tissue degradation, hemolysis and sepsis in vivo. Results: In ...
  • Genome sequence of the parainfluenza virus 5 strain that persistently infects AGS cells 

    Wignall-Fleming, Elizabeth; Young, Dan Frushard; Goodburn, Steve; Davison, Andrew J.; Randall, Richard Edward (2016-07-21) - Journal article
    We have sequenced the parainfluenza virus 5 strain that persistently infects the commonly used AGS human cell line without causing cytopathology. This virus is most closely related to human strains, indicating that it may ...
  • Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting 

    Tong, Steven Y C; Holden, Matthew T G; Nickerson, Emma K; Cooper, Ben S; Köser, Claudio U; Cori, Anne; Jombart, Thibaut; Cauchemez, Simon; Fraser, Christophe; Wuthiekanun, Vanaporn; Thaipadungpanit, Janjira; Hongsuwan, Maliwan; Day, Nicholas P; Limmathurotsakul, Direk; Parkhill, Julian; Peacock, Sharon J (2014-12-09) - Journal article
    Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial infection. Whole-genome sequencing of MRSA has been used to define phylogeny and transmission in well-resourced healthcare settings, yet the ...
  • Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen Burkholderia pseudomallei K96243 

    Dowling, Andrea J.; Wilkinson, Paul A.; Holden, Matthew T. G.; Quail, Michael A.; Bentley, Stephen D.; Reger, Julia; Waterfield, Nicholas R.; Titball, Richard W.; Ffrench-Constant, Richard H. (2010-12-22) - Journal article
    Burkholderia pseudomallei is an important human pathogen whose infection biology is still poorly understood. The bacterium is endemic to tropical regions, including South East Asia and Northern Australia, where it causes ...
  • Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment 

    Nudel, Ron; Simpson, Nuala H; Baird, Gillian; O'Hare, Anne; Conti-Ramsden, Gina; Bolton, Patrick F; Hennessy, Elizabeth R; Ring, Susan M; Smith, George Davey; Francks, Clyde; Paracchini, Silvia; Monaco, Anthony P; Fisher, Simon E; Newbury, Dianne F; the SLI Consortium (2014-04) - Journal article
    Specific language impairment (SLI) is a neurodevelopmental disorder that affects linguistic abilities when development is otherwise normal. We report the results of a genome-wide association study of SLI which included ...
  • Genome-wide DNA methylation patterns in wild samples of two morphotypes of threespine stickleback (Gasterosteus aculeatus) 

    Smith, Gilbert; Smith, Carl; Kenny, John; Chaudhuri, Roy; Ritchie, Michael Gordon (2015-04) - Journal article
    Epigenetic marks such as DNA methylation play important biological roles in gene expression regulation and cellular differentiation during development. To examine whether DNA methylation patterns are potentially associated ...