Now showing items 1-20 of 209

  • 17ß-Estradiol protects against the effects of a high fat diet on cardiac glucose, lipid and nitric oxide metabolism in rats 

    Zafirovic, Sonja; Obradovic, Milan; Sudar-Milovanovic, Emina; Jovanovic, Aleksandra; Stanimirovic, Julijana; Stewart, Alan J.; Pitt, Samantha J.; Isenovic, Esma R. (2017-05-05) - Journal article
    The aim of this study was to investigate the in vivo effects of estradiol (E2) on myocardial metabolism and inducible nitric oxide synthase (iNOS) expression/activity in obese rats. Male Wistar rats were fed with a normal ...
  • 5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer 

    Uribe-Lewis, Santiago; Stark, Rory; Carroll, Thomas; Dunning, Mark J.; Bachman, Martin; Ito, Yoko; Stojic, Lovorka; Halim, Silvia; Vowler, Sarah L.; Lynch, Andy G.; Delatte, Benjamin; de Bony, Eric J.; Colin, Laurence; Defrance, Matthieu; Krueger, Felix; Silva, Ana Luisa; ten Hoopen, Rogier; Ibrahim, Ashraf E.K.; Fuks, François; Murrell, Adele (2015-04-01) - Journal article
    Background : The discovery of cytosine hydroxymethylation (5hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behaviour in colon cancer. 5hmC is ...
  • 5-hydroxymethylcytosine profiling as an indicator of cellular state 

    Laird, Alexander; Thomson, John P.; Harrison, David J.; Meehan, Richard R. (2013-12) - Journal article
    DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including ...
  • Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF) 

    Kailainathan, Sumangali; Piers, Thomas M.; Yi, Jee Hyun; Choi, Seongmin; Fahey, Mark S.; Borger, Eva; Gunn-Moore, Francis James; O'Neill, Laurie; Lever, Michael; Whitcomb, Daniel J.; Cho, Kwangwook; Allen, Shelley J. (2016-02) - Journal article
    This study describes a fundamental functional difference between the two main polymorphisms of the pro-form of brain-derived neurotrophic factor (proBDNF), providing an explanation as to why these forms have such different ...
  • "Adaptive response" - some underlying mechanisms and open questions 

    Dimova, Evgeniya G; Bryant, Peter Edward; Chankova, Stephka G (2008) - Journal article
    Organisms are affected by different DNA damaging agents naturally present in the environment or released as a result of human activity. Many defense mechanisms have evolved in organisms to minimize genotoxic damage. One ...
  • Adaptive sequence evolution is driven by biotic stress in a pair of orchid species (Dactylorhiza) with distinct ecological optima 

    Balao, Francisco; Trucchi, Emiliano; Wolfe, Thomas; Hao, Bao-Hai; Lorenzo, Maria Teresa; Baar, Juliane; Sedman, Laura; Kosiol, Carolin; Amman, Fabian; Chase, Mark W.; Hedrén, Mikael; Paun, Ovidiu (2017-07-04) - Journal article
    The orchid family is the largest in the angiosperms, but little is known about the molecular basis of the significant variation they exhibit. We investigate here the transcriptomic divergence between two European terrestrial ...
  • Amphioxus regeneration : evolutionary and biomedical implications 

    Somorjai, Ildiko Maureen Lara (2017-12-21) - Journal item
    Regeneration is a variable trait in chordates, with some species capable of impressive abilities, and others of only wound healing with scarring. Regenerative capacity has been reported in the literature for 5 species from ...
  • Amphioxus SYCP1 : a case of retrogene replacement and co-option of regulatory elements adjacent to the ParaHox cluster 

    Garstang, Myles G.; Ferrier, David E. K. (2018-01-02) - Journal article
    Retrogenes are formed when an mRNA is reverse transcribed and re-inserted into the genome in a location unrelated to the original locus. If this retrocopy inserts into a transcriptionally favourable locus and is able to ...
  • Ancient polymorphisms and divergence hitchhiking contribute to genomic islands of divergence within a poplar species complex 

    Ma, Tao; Wang, Kun; Hu, Quanjun; Xi, Zhenxiang; Wan, Dongshi; Wang, Qian; Feng, Jianju; Jiang, Dechun; Ahani, Hamid; Abbott, Richard John; Lascoux, Martin; Nevo, Eviatar; Liu, Jianquan (2018-01-09) - Journal article
    How genome divergence eventually leads to speciation is a topic of prime evolutionary interest. Genomic islands of elevated divergence are frequently reported between diverging lineages, and their size is expected to ...
  • Annelid Distal-less/Dlx duplications reveal varied post-duplication fates 

    McDougall, Carmel; Korchagina, Natalia; Tobin, Johnathan; Ferrier, David Ellard Keith (2011-08-16) - Journal article
    Background: Dlx (Distal-less) genes have various developmental roles and are widespread throughout the animal kingdom, usually occurring as single copy genes in non-chordates and as multiple copies in most chordate genomes. ...
  • Another biomineralising protostome with an msp130 gene and conservation of msp130 gene structure across Bilateria 

    Szabo, Réka; Ferrier, David Ellard Keith (2015-05) - Journal article
    Msp130 genes are known for their association with biomineralisation, principally in echinoderm skeletogenesis. Recently, msp130 genes were shown to exist more widely across the animal kingdom, including in molluscs, and a ...
  • Anti-Müllerian hormone serum concentrations of women with germline BRCA1 or BRCA2 mutations 

    Phillips, K-A; Collins, I M; Milne, R L; McLachlan, S A; Friedlander, M; Hickey, M; Stern, C; Hopper, J L; Fisher, R; Kannemeyer, G; Picken, S; Smith, C D; Kelsey, Thomas William; Anderson, R A (2016-05) - Journal article
    Study question: Do women with BRCA1 and BRCA2 mutations have reduced ovarian reserve, as measured by circulating anti-müllerian hormone (AMH) concentration?  Summary answer: Women with a germline mutation in BRCA1 have ...
  • APE-type non-LTR retrotransposons of multicellular organisms encode virus-like 2A oligopeptide sequences, which mediate translational recoding during protein synthesis 

    Odon, Valerie Marie Nathalie; Luke, Garry Alec; Roulston, Claire; De Felipe, Pablo; Ruan, Lin; Escuin, Helena; Brown, Jeremy; Ryan, Martin Denis; Sukhodub, Andriy (2013-08) - Journal article
    2A oligopeptide sequences (“2As”) mediate a cotranslational recoding event termed “ribosome skipping.” Previously we demonstrated the activity of 2As (and “2A-like sequences”) within a wide range of animal RNA virus genomes ...
  • Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data 

    Camacho, Niedzica; Van Loo, Peter; Edwards, Sandra; Kay, Jonathan D.; Matthews, Lucy; Haase, Kerstin; Clark, Jeremy; Dennis, Nening; Thomas, Sarah; Kremeyer, Barbara; Zamora, Jorge; Butler, Adam P.; Gundem, Gunes; Merson, Sue; Luxton, Hayley; Hawkins, Steve; Ghori, Mohammed; Marsden, Luke; Lambert, Adam; Karaszi, Katalin; Pelvender, Gill; Massie, Charlie E.; Kote-Jarai, ZSofia; Raine, Keiran; Jones, David; Howat, William J.; Hazell, Steven; Livni, Naomi; Fisher, Cyril; Ogden, Christopher; Kumar, Pardeep; Thompson, Alan; Nicol, David; Mayer, Erik; Dudderidge, Tim; Yu, Yongwei; Zhang, Hongwei; Shah, Nimish C.; Gnanapragasam, Vincent J.; Group, The CRUK-ICGC Prostate; Isaacs, William; Visakorpi, Tapio; Hamdy, Freddie; Berney, Dan; Verrill, Clare; Warren, Anne Y.; Wedge, David C.; Lynch, Andrew G.; Foster, Christopher S.; Lu, Yong Jie; Bova, G. Steven; Whitaker, Hayley C.; McDermott, Ultan; Neal, David E.; Eeles, Rosalind; Cooper, Colin S.; Brewer, Daniel S. (2017-09-25) - Journal article
    A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively ...
  • Assessing recent selection and functionality at long noncoding RNA loci in the mouse genome 

    Wiberg, Ralf Axel Wilhelm; Halligan, Daniel L.; Ness, Rob W.; Necsulea, Anamaria; Kaessmann, Henrik; Keightley, Peter D. (2015-08) - Journal article
    Long noncoding RNAs (lncRNAs) are one of the most intensively studied groups of noncoding elements. Debate continues over what proportion of lncRNAs are functional or merely represent transcriptional noise. Although ...
  • Assessment of enzyme inhibition : a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs 

    Ramsay, Rona R.; Tipton, Keith F. (2017-07) - Journal item
    The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several pharmacological purposes. This review ...
  • Association between common variation at the FTO locus and changes in Body Mass Index from infancy to late childhood : the complex nature of genetic association through growth and development 

    Sovio, Ulla; Mook-Kanamori, Dennis O.; Warrington, Nicole M.; Lawrence, Robert; Briollais, Laurent; Palmer, Colin N.A.; Cecil, Joanne Elizabeth; Sandling, Johanna; Syvänen, Ann-Christine; Kaakinen, Marika; Beilin, Lawrie; Millwood, Iona; Bennett, Amanda; Laitinen, Jaana; Pouta, Anneli; Molitor, John; Davey Smith, George; Ben-Shlomo, Yoav; Jaddoe, Vincent; Palmer, Lyle; Pennell, Craig; Cole, Tim; McCarthy, Mark; Järvelin, Marjo-Riitta; Timpson, Nicholas (2011) - Journal article
    An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We metaanalyzed associations between the FTO locus (rs9939609) and BMI in samples, aged from early infancy to 13 years, ...
  • Asymmetric paternal effect on offspring size linked to parent-of-origin expression of an insulin-like growth factor 

    Saldivar Lemus, Yolitzi; Vielle-Calzada, Jean-Philippe; Ritchie, Michael G.; Macías Garcia, Constantino (2017-06) - Journal article
    Sexual reproduction brings together reproductive partners whose long-term interests often differ, raising the possibility of conflict over their reproductive investment. Males that enhance maternal investment in their ...
  • At the transition from invertebrates to vertebrates a novel GnRH-like peptide emerges in amphioxus 

    Roch, Graeme; Tello, Javier; Sherwood, Nancy (2013-12-20) - Journal article
    Gonadotropin-releasing hormone (GnRH) is a critical reproductive regulator in vertebrates. Homologous peptides are also found in invertebrates, with a variety of characterized functions. In the amphioxus, an invertebrate ...
  • Authentication and characterisation of a new oesophageal adenocarcinoma cell line : MFD-1 

    Garcia, Edwin; Hayden, Annette; Birts, Charles; Britton, Edward; Cowie, Andrew; Pickard, Karen; Mellone, Massimiliano; Choh, Clarisa; Derouet, Mathieu; Duriez, Patrick; Noble, Fergus; White, Michael J.; Primrose, John N.; Strefford, Jonathan C.; Rose-Zerilli, Matthew; Thomas, Gareth J.; Ang, Yeng; Sharrocks, Andrew D.; Fitzgerald, Rebecca C.; Underwood, Timothy J.; Lynch, Andy G. (2016-09-07) - Journal article
    New biological tools are required to understand the functional significance of genetic events revealed by whole genome sequencing (WGS) studies in oesophageal adenocarcinoma (OAC). The MFD-1 cell line was isolated from a ...