Now showing items 1-20 of 181

  • 5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer 

    Uribe-Lewis, Santiago; Stark, Rory; Carroll, Thomas; Dunning, Mark J.; Bachman, Martin; Ito, Yoko; Stojic, Lovorka; Halim, Silvia; Vowler, Sarah L.; Lynch, Andy G.; Delatte, Benjamin; de Bony, Eric J.; Colin, Laurence; Defrance, Matthieu; Krueger, Felix; Silva, Ana Luisa; ten Hoopen, Rogier; Ibrahim, Ashraf E.K.; Fuks, François; Murrell, Adele (2015-04-01) - Journal article
    Background : The discovery of cytosine hydroxymethylation (5hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behaviour in colon cancer. 5hmC is ...
  • 5-hydroxymethylcytosine profiling as an indicator of cellular state 

    Laird, Alexander; Thomson, John P.; Harrison, David J.; Meehan, Richard R. (2013-12) - Journal article
    DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including ...
  • Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF) 

    Kailainathan, Sumangali; Piers, Thomas M.; Yi, Jee Hyun; Choi, Seongmin; Fahey, Mark S.; Borger, Eva; Gunn-Moore, Francis James; O'Neill, Laurie; Lever, Michael; Whitcomb, Daniel J.; Cho, Kwangwook; Allen, Shelley J. (2016-02) - Journal article
    This study describes a fundamental functional difference between the two main polymorphisms of the pro-form of brain-derived neurotrophic factor (proBDNF), providing an explanation as to why these forms have such different ...
  • "Adaptive response" - some underlying mechanisms and open questions 

    Dimova, Evgeniya G; Bryant, Peter Edward; Chankova, Stephka G (2008) - Journal article
    Organisms are affected by different DNA damaging agents naturally present in the environment or released as a result of human activity. Many defense mechanisms have evolved in organisms to minimize genotoxic damage. One ...
  • Adaptive sequence evolution is driven by biotic stress in a pair of orchid species (Dactylorhiza) with distinct ecological optima 

    Balao, Francisco; Trucchi, Emiliano; Wolfe, Thomas; Hao, Bao-Hai; Lorenzo, Maria Teresa; Baar, Juliane; Sedman, Laura; Kosiol, Carolin; Amman, Fabian; Chase, Mark W.; Hedrén, Mikael; Paun, Ovidiu (2017-07-04) - Journal article
    The orchid family is the largest in the angiosperms, but little is known about the molecular basis of the significant variation they exhibit. We investigate here the transcriptomic divergence between two European terrestrial ...
  • Annelid Distal-less/Dlx duplications reveal varied post-duplication fates 

    McDougall, Carmel; Korchagina, Natalia; Tobin, Johnathan; Ferrier, David Ellard Keith (2011-08-16) - Journal article
    Background: Dlx (Distal-less) genes have various developmental roles and are widespread throughout the animal kingdom, usually occurring as single copy genes in non-chordates and as multiple copies in most chordate genomes. ...
  • Another biomineralising protostome with an msp130 gene and conservation of msp130 gene structure across Bilateria 

    Szabo, Réka; Ferrier, David Ellard Keith (2015-05) - Journal article
    Msp130 genes are known for their association with biomineralisation, principally in echinoderm skeletogenesis. Recently, msp130 genes were shown to exist more widely across the animal kingdom, including in molluscs, and a ...
  • Anti-Müllerian hormone serum concentrations of women with germline BRCA1 or BRCA2 mutations 

    Phillips, K-A; Collins, I M; Milne, R L; McLachlan, S A; Friedlander, M; Hickey, M; Stern, C; Hopper, J L; Fisher, R; Kannemeyer, G; Picken, S; Smith, C D; Kelsey, Thomas William; Anderson, R A (2016-05) - Journal article
    Study question: Do women with BRCA1 and BRCA2 mutations have reduced ovarian reserve, as measured by circulating anti-müllerian hormone (AMH) concentration?  Summary answer: Women with a germline mutation in BRCA1 have ...
  • APE-type non-LTR retrotransposons of multicellular organisms encode virus-like 2A oligopeptide sequences, which mediate translational recoding during protein synthesis 

    Odon, Valerie Marie Nathalie; Luke, Garry Alec; Roulston, Claire; De Felipe, Pablo; Ruan, Lin; Escuin, Helena; Brown, Jeremy; Ryan, Martin Denis; Sukhodub, Andriy (2013-08) - Journal article
    2A oligopeptide sequences (“2As”) mediate a cotranslational recoding event termed “ribosome skipping.” Previously we demonstrated the activity of 2As (and “2A-like sequences”) within a wide range of animal RNA virus genomes ...
  • Assessing recent selection and functionality at long noncoding RNA loci in the mouse genome 

    Wiberg, Ralf Axel Wilhelm; Halligan, Daniel L.; Ness, Rob W.; Necsulea, Anamaria; Kaessmann, Henrik; Keightley, Peter D. (2015-08) - Journal article
    Long noncoding RNAs (lncRNAs) are one of the most intensively studied groups of noncoding elements. Debate continues over what proportion of lncRNAs are functional or merely represent transcriptional noise. Although ...
  • Assessment of enzyme inhibition : a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs 

    Ramsay, Rona R.; Tipton, Keith F. (2017-07) - Journal item
    The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several pharmacological purposes. This review ...
  • Association between common variation at the FTO locus and changes in Body Mass Index from infancy to late childhood : the complex nature of genetic association through growth and development 

    Sovio, Ulla; Mook-Kanamori, Dennis O.; Warrington, Nicole M.; Lawrence, Robert; Briollais, Laurent; Palmer, Colin N.A.; Cecil, Joanne Elizabeth; Sandling, Johanna; Syvänen, Ann-Christine; Kaakinen, Marika; Beilin, Lawrie; Millwood, Iona; Bennett, Amanda; Laitinen, Jaana; Pouta, Anneli; Molitor, John; Davey Smith, George; Ben-Shlomo, Yoav; Jaddoe, Vincent; Palmer, Lyle; Pennell, Craig; Cole, Tim; McCarthy, Mark; Järvelin, Marjo-Riitta; Timpson, Nicholas (2011) - Journal article
    An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We metaanalyzed associations between the FTO locus (rs9939609) and BMI in samples, aged from early infancy to 13 years, ...
  • Asymmetric paternal effect on offspring size linked to parent-of-origin expression of an insulin-like growth factor 

    Saldivar Lemus, Yolitzi; Vielle-Calzada, Jean-Philippe; Ritchie, Michael G.; Macías Garcia, Constantino (2017-06) - Journal article
    Sexual reproduction brings together reproductive partners whose long-term interests often differ, raising the possibility of conflict over their reproductive investment. Males that enhance maternal investment in their ...
  • At the transition from invertebrates to vertebrates a novel GnRH-like peptide emerges in amphioxus 

    Roch, Graeme; Tello, Javier; Sherwood, Nancy (2013-12-20) - Journal article
    Gonadotropin-releasing hormone (GnRH) is a critical reproductive regulator in vertebrates. Homologous peptides are also found in invertebrates, with a variety of characterized functions. In the amphioxus, an invertebrate ...
  • Authentication and characterisation of a new oesophageal adenocarcinoma cell line : MFD-1 

    Garcia, Edwin; Hayden, Annette; Birts, Charles; Britton, Edward; Cowie, Andrew; Pickard, Karen; Mellone, Massimiliano; Choh, Clarisa; Derouet, Mathieu; Duriez, Patrick; Noble, Fergus; White, Michael J.; Primrose, John N.; Strefford, Jonathan C.; Rose-Zerilli, Matthew; Thomas, Gareth J.; Ang, Yeng; Sharrocks, Andrew D.; Fitzgerald, Rebecca C.; Underwood, Timothy J.; Lynch, Andy G. (2016-09-07) - Journal article
    New biological tools are required to understand the functional significance of genetic events revealed by whole genome sequencing (WGS) studies in oesophageal adenocarcinoma (OAC). The MFD-1 cell line was isolated from a ...
  • Axonal localization of integrins in the CNS is neuronal type and age dependent 

    Andrews, Melissa Renee; Soleman, Sara; Cheah, Menghon; Tumbarello, David; Mason, Matthew; Moloney, Elizabeth; Verhaagen, Joost; Bensadoun, Jean-Charles; Schneider, Bernard; Aebischer, Patrick; Fawcett, James (2016-07) - Journal article
    The regenerative ability of CNS axons decreases with age however this ability remains largely intact in PNS axons throughout adulthood. These differences are likely to correspond with age-related silencing of proteins ...
  • Biology, physiology and gene expression of grasshopper Oedaleus asiaticus exposed to diet stress from plant secondary compounds 

    Huang, Xunbing; Ma, Jingchuan; Qin, Xinghu; Tu, Xiongbing; Cao, Guangchun; Wang, Guangjun; Nong, Xiangqun; Zhang, Zehua (2017-08-17) - Journal article
    We studied the role of plant primary and secondary metabolites in mediating plant-insect interactions by conducting a no-choice single-plant species field experiment to compare the suitability, enzyme activities, and gene ...
  • Burkholderia pseudomallei genome plasticity associated with genomic island variation 

    Tumapa, Sarinna; Holden, Matthew T. G.; Vesaratchavest, Mongkol; Wuthiekanun, Vanaporn; Limmathurotsakul, Direk; Chierakul, Wirongrong; Feil, Edward J.; Currie, Bart J.; Day, Nicholas P. J.; Nierman, William C.; Peacock, Sharon J. (2008-04-25) - Journal article
    Background: Burkholderia pseudomallei is a soil-dwelling saprophyte and the cause of melioidosis. Horizontal gene transfer contributes to the genetic diversity of this pathogen and may be an important determinant of virulence ...
  • Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles 

    Nandi, Tannistha; Holden, Matthew; Didelot, Xavier; Mehershahi, Kurosh; Boddey, Justin A; Beacham, Ifor; Peak, Ian; Harting, John; Baybayan, Primo; Guo, Yan; Wang, Susana; How, Lee Chee; Sim, Bernice; Essex-Lopresti, Angela; Sarkar-Tyson, Mitali; Nelson, Michelle; Smither, Sophie; Ong, Catherine; Aw, Lay Tin; Hoon, Chua Hui; Michell, Stephen; Studholme, David J; Titball, Richard; Chen, Swaine L; Parkhill, Julian; Tan, Patrick (2015-01) - Journal article
    Burkholderia pseudomallei (Bp) is the causative agent of the infectious disease melioidosis. To investigate population diversity, recombination, and horizontal gene transfer in closely related Bp isolates, we performed ...
  • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist : a Mendelian randomisation analysis 

    Freitag, D.; Butterworth, A.S.; Willeit, P.; Howson, J.M.M.; Burgess, S.; Kaptoge, S.; Young, R.; Ho, W.K.; Wood, A.M.; Sweeting, M.; Spackman, S.; Staley, J.R.; Ramond, A.; Harshfield, E.; Nielsen, S.F.; Grande, P.; Lange, L.A.; Bown, M.J.; Jones, G.T.; Scott, R.A.; Bevan, S.; Porcu, E.; Thorleifsson, G.; Zeng, L.; Kessler, T.; Nikpay, M.; Do, R.; Zhang, W.; Hopewell, J.C.; Kleber, M.; Delgado, G.E.; Nelson, C.P.; Goel, A.; Bis, J.C.; Dehghan, A.; Ligthart, S.; Smith, A.V.; Qu, L.; van 't Hof, F.N.G.; de Bakker, P.I.W.; Baas, A.F.; van Rij, A.; Tromp, G.; Kuivaniemi, H.; Ritchie, M.D.; Verma, S.S.; Crawford, D.C.; Malinowski, J.; de Andrade, M.; Kullo, I.J.; Peissig, P.L.; McCarty, C.A.; Böttinger, E.P.; Gottesman, O.; Crosslin, D.R.; Carrell, D.S.; Rasmussen-Torvik, L.J.; Pacheco, J.A.; Huang, J.; Timpson, N.J.; Kettunen, J.; Ala-Korpela, M.; Mitchell, G.F.; Parsa, A.; Wilkinson, I.B.; Gorski, M.; Li, Y.; Franceschini, N.; Keller, M.F.; Ganesh, S.K.; Langefeld, C.D.; Bruijn, L.; Brown, M.A.; Evans, D.M.; Baltic, S.; Ferreira, M.A.; Baurecht, H.; Weidinger, S.; Franke, A.; Lubitz, S.A.; Müller-Nurasyid, M.; Felix, J.F.; Smith, N.L.; Sudman, M.; Thompson, S.D.; Zeggini, E.; Panoutsopoulou, K.; Nalls, M.A.; Singleton, A.; Polychronakos, C.; Bradfield, J.P.; Hakonarson, H.; Easton, D.F.; Thompson, D.; Tomlinson, I.P.; Dunlop, M.; Hemminki, K.; Morgan, G.; Eisen, T.; Goldschmidt, H.; Allan, J.M.; Henrion, M.; Whiffin, N.; Wang, Y.; Chubb, D.; Iles, M.M.; Bishop, D.T.; Law, M.H.; Hayward, N.K.; Luo, Y.; Nejentsev, S.; Barbalic, M.; Crossman, D.; Sanna, S.; Soranzo, N.; Markus, H.S.; Wareham, N.J.; Rader, D.J.; Reilly, M.; Assimes, T.; Harris, T.B.; Hofman, A.; Franco, O.H.; Gudnason, V.; Tracy, R.; Psaty, B.M.; Farrall, M.; Watkins, H.; Hall, A.S.; Samani, N.J.; März, W.; Clarke, R.; Collins, R.; Kooner, J.S.; Chambers, J.C.; Kathiresan, S.; McPherson, R.; Erdmann, J.; Kastrati, A.; Schunkert, H.; Stefánsson, K.; Thorsteinsdottir, U.; Walston, J.D.; Tybjærg-Hansen, A.; Alam, D.S.; Al Shafi Majumder, A.; Angelantonio, E.D.; Chowdhury, R.; Nordestgaard, B.G.; Saleheen, D.; Thompson, S.G.; Danesh, J.; Houlston, R.S. (2015-04-01) - Journal article
    To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. ...