Now showing items 21-40 of 699

  • Acetylation site specificities of lysine deacetylase inhibitors in human cells 

    Schölz, Christian; Weinert, Brian T.; Wagner, Sebastian A.; Beli, Petra; Miyake, Yasuyuki; Qi, Yun; Jensen, Lars J.; Streicher, Werner; McCarthy, Anna Rose; Westwood, Nicholas James; Lain, Sonya; Cox, Jürgen; Matthias, Patrick; Mann, Matthias; Bradner, James E.; Choudhary, Chunaram (2015) - Journal article
    Lysine deacetylases inhibitors (KDACIs) are used in basic research, and many are being investigated in clinical trials for treatment of cancer and other diseases. However, their specificities in cells are incompletely ...
  • Acetylene hydrogenation over structured Au-Pd catalysts 

    McCue, Alan J.; Baker, Richard; Anderson, James A. (2016-07-01) - Journal article
    AuPd nanoparticles were prepared following a methodology designed to produce core-shell structures (Au core and Pd shell). Characterisation suggested slow addition of the shell metal favoured deposition onto the pre-formed ...
  • The activation of Woollins' reagent. Isolation of pyridine stabilised PhPSe2 

    Ascherl, Laura; Nordheider, Andreas; Athukorala Arachchige, Kasun Sankalpa; Cordes, David Bradford; Karaghiosoff, Konstantin; Buehl, Michael; Slawin, Alexandra Martha Zoya; Woollins, J Derek (2014-06-14) - Journal article
    Woollins' reagent (WR, (PhPSe2)2) plays an essential role in the selenation of organic compounds. Reaction of WR with pyridine gives the P(V) species PhPSe2 stabilised by pyridine coordination which is the first ...
  • The ADOR mechanism for the synthesis of new zeolites 

    Eliášová, P.; Opanasenko, M.; Wheatley, Paul Stewart; Shamzhy, M.; Mazur, M.; Nachtigall, P.; Roth, W.J.; Morris, Russell Edward; Čejka, J. (2015-10-21) - Journal article
    A novel methodology, called ADOR (assembly-disassembly-organisation-reassembly), for the synthesis of zeolites is reviewed here in detail. The ADOR mechanism stems from the fact that certain chemical weakness against a ...
  • Adsorption materials and processes for carbon capture from gas-fired power plants : AMPGas 

    Gibson, J. A. Arran; Mangano, Enzo; Shiko, Elenica; Greenaway, Alex; Gromov, Andrei V.; Lozinska, Magdalena M.; Friedrich, Daniel; Campbell, Eleanor E. B.; Wright, Paul A.; Brandani, Stefano (2016-04-06) - Journal article
    The key challenge in postcombustion capture from gas-fired power plants is related to the low CO2 concentration in the flue gas (4–8% by volume). This means that conventional amine processes will result in a relatively ...
  • Adsorption of a dihydro-TTF derivative on Au(111) via a thiolate bonding complex to gold adatoms 

    Jethwa, Siddharth Janak; Grillo, Federico; Fruchtl, Herbert Anton; Simpson, Grant James; Treanor, Michael John; Schaub, Renald; Francis, Stephen Malcolm; Richardson, Neville V; Aitken, R Alan (2014-08-05) - Journal article
    A dihydro-TTF derivative with four acetyl-protected thiol ligands was synthesised and adsorbed on Au(111) under UHV conditions. Scanning Tunnelling Microscopy (STM) and Infrared (IR) spectroscopy show that self-organised ...
  • The AEROPATH project targeting Pseudomonas aeruginosa : crystallographic studies for assessment of potential targets in early-stage drug discovery 

    Moynie, Lucile; Schnell, Robert; McMahon, Stephen A.; Sandalova, Tatyana; Abdelli Boulkeroua, Wassila; Schmidberger, Jason W.; Alphey, Magnus; Cukier, Cyprian; Duthie, Fraser; Kopec, Jolanta; Liu, Huanting; Jacewicz, Agata; Hunter, William N.; Naismith, James H.; Schneider, Gunter (2013-01) - Journal article
    Bacterial infections are increasingly difficult to treat owing to the spread of antibiotic resistance. A major concern is Gram-negative bacteria, for which the discovery of new antimicrobial drugs has been particularly ...
  • ALDH2 mediates 5-nitrofuran activity in multiple species 

    Zhou, Linna; Ishizaki, Hironori; Spitzer, Michaela; Taylor, Kerrie; Temperley, Nicholas; Johnson, Stephen; Brear, Paul; Gautier, Philippe; Zeng, Zhiqiang; Mitchell, Amy; Narayan, Vikram; McNeil, Ewan; Melton, David; Smith, Terry K; Tyers, Mike; Westwood, Nicholas James; Patton, Elizabeth (2012-07-27) - Journal article
    Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of pro-drugs widely used to treat bacterial and trypanosome infections, ...
  • All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarised cyclohexane 

    Keddie, Neil Steven; Slawin, Alexandra Martha Zoya; Lebl, Tomas; Philp, Douglas; O'Hagan, David (2015-04) - Journal article
    The highest-energy stereoisomer of 1,2,3,4,5,6-hexafluorocyclohexane, in which all of the fluorines are ‘up’, is prepared in a 12-step protocol. The molecule adopts a classic chair conformation with alternate C–F bonds ...
  • alpha-Ketophosphonates as ester surrogates : isothiourea-catalyzed asymmetric diester and lactone synthesis 

    Smith, Siobhan R.; Leckie, Stuart M.; Holmes, Reuben; Douglas, James; Fallan, Charlene; Shapland, Peter; Pryde, David; Slawin, Alexandra M. Z.; Smith, Andrew D. (2014-05-02) - Journal article
    Isothiourea HBTM-2.1 catalyzes the asymmetric Michael addition/lactonization of aryl- and alkenylacetic acids using α-keto-β,γ-unsaturated phosphonates as α,β-unsaturated ester surrogates, giving access to a diverse range ...
  • Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli 

    Lou, Hubing; Chen, Min; Black, Susan S.; Bushell, Simon R.; Ceccarelli, Matteo; Mach, Tivadar; Beis, Konstantinos; Low, Alison S.; Bamford, Victoria A.; Booth, Ian R.; Bayley, Hagan; Naismith, James H. (2011-10-28) - Journal article
    Antibiotic-resistant bacteria, particularly Gram negative species, present significant health care challenges. The permeation of antibiotics through the outer membrane is largely effected by the porin superfamily, changes ...
  • Ammonium Phenylphosphonamidodiselenoates and Phenylphosphonamidodi-selenoic Diamides from the Selenation of Primary and Secondary Amines 

    Hua, Guoxiong; Randall, Rebecca A. M.; Slawin, Alexandra M. Z.; Woollins, J. Derek (2011-10) - Journal article
    By reacting two equivalents of primary or secondary amines with 2,4-bis(phenyl)-1,3-diselenadiphosphetane-2,4-diselenide (Woollins' reagent) at room temperature a series of new ammonium phenylphosphonamidodiselenoates 1-7 ...
  • Analysis of CF···FC interactions on cyclohexane and naphthalene frameworks 

    Cormanich, Rodrigo A.; Rittner, Roberto; O'Hagan, David; Buehl, Michael (2014-09-11) - Journal article
    Intramolecular CF···FC interactions in selected organofluorine compounds (all-syn-1,2,3,4- and all-syn-1,2,4,5-tetrafluorocyclohexane, 1,8-difluoronaphthalene, 4,5-difluorophenanthrene, 2,2′,5,5′-tetrafluorobiphenyl) were ...
  • Analysis of influenza A virus NS1 dimer interfaces in solution by pulse EPR distance measurements 

    Kerry, Philip S; Turkington, Hannah L; Ackermann, Katrin; Jameison, Stephen A; Bode, Bela Ernest (2014-08-22) - Journal article
    Pulsed electron-electron double resonance (PELDOR) is an electron paramagnetic resonance (EPR) spectroscopy technique for nanometer distance measurements between paramagnetic centres such as radicals. PELDOR has been ...
  • Analysis of the intrinsically disordered N-terminus of the DNA junction-resolving enzyme T7 endonuclease I : identification of structure formed upon DNA binding 

    Freeman, Alasdair D J; Stevens, Michael; Declais, Anne Cecile; Leahy, Adam; Mackay, Katherine; El Mkami, Hassane; Lilley, David M. J.; Norman, David G. (2016-08-02) - Journal article
    The four-way (Holliday) DNA junction of homologous recombination is processed by the symmetrical cleavage of two strands by a nuclease. These junction-resolving enzymes bind to four-way junctions in dimeric form, distorting ...
  • Anhydrides as α,β-unsaturated acyl ammonium precursors : isothiourea-promoted catalytic asymmetric annulation processes 

    Robinson, Emily R. T.; Fallan, Charlene; Simal, Carmen; Slawin, Alexandra M. Z.; Smith, Andrew D. (2013) - Journal article
    The asymmetric annulation of a range of alpha,beta-unsaturated acyl ammonium intermediates, formed from isothiourea HBTM 2.1 and anhydrides with either 1,3-dicarbonyls, beta-ketoesters or azaaryl ketones gives either ...
  • Anomalous oxidation of Fe-Si alloys under a low oxygen pressure at 800 °C 

    Liu, L.L.; Guo, Q.Q.; Liu, S.; Ni, C.S.; Niu, Y. (2015) - Journal article
    Abstract The oxidation of three Fe-xSi alloys (x = 5, 9, 13 at.%) under 10−20 atm O2 at 800 °C formed in all cases SiO2 layers. For Fe-5Si this layer broke down and healed up periodically forming an anomalous internal ...
  • Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells 

    Amin, Hiren P.; Czank, Charles; Raheem, Saki; Zhang, Qingzhi; Botting, Nigel P.; Cassidy, Aedín; Kay, Colin D. (2015-06-02) - Journal article
    Scope : In vitro and in vivo studies suggest that dietary anthocyanins modulate cardiovascular disease risk; however, given anthocyanins extensive metabolism, it is likely that their degradation products and conjugated ...
  • The application of a novel fluidised photo reactor under UV-Visible and natural solar irradiation in the photocatalytic generation of hydrogen 

    Skillen, Nathan; Adams, Morgan; McCullagh, Cathy; Ryu, Su Young; Fina, Federica; Hoffman, Michael R.; Irvine, John Thomas Sirr; Robertson, Peter K. J. (2016-02-15) - Journal article
    With advancements in the development of visible light responsive catalysts for H2 production frequently being reported, photocatalytic water splitting has become an attractive method as a potential ‘solar fuel generator’. ...
  • Application of exsolved structures as a route to more robust anodes for improved biogas utilisation in SOFCs 

    Cassidy, Mark; Gamble, Stephen Richard; Irvine, John Thomas Sirr (Electrochemical Society, 2015-07-17) - Conference item
    Biogas is a potentially readily available fuel which could be especially useful when combined with the efficient energy conversion in SOFCs. This could be especially important in rural or remote locations where grid ...