Now showing items 1-4 of 4

  • Cell cycle control and its modulation in HPV infected cells 

    Lyman, Rachel C. (University of St Andrews, 2010-07) - Thesis
    A key effect of human papillomavirus (HPV) infection is to disrupt the normal cell cycle in order to subvert the cellular DNA replication machinery. Morphologically, condylomata induced by high and low risk HPV types cannot ...
  • Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6 

    MacCallum, Stephanie F.; Groves, Michael J.; James, John; Murray, Karen; Appleyard, Virginia; Prescott, Alan R.; Drbal, Abed A.; Nicolaou, Anna; Cunningham, Joan; Haydock, Sally; Ganley, Ian G.; Westwood, Nicholas J.; Coates, Philip J.; Lain, Sonia; Tauro, Sudhir (2013-02-14) - Journal article
    Tenovin-6 (Tnv-6) is a bioactive small molecule with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-apoptotic effects of Tnv-6 ...
  • The effects of leptomycin B on HPV-infected cells 

    Jolly, Carol E (University of St Andrews, 2008) - Thesis
    Cervical cancer is a major cause of death in women and is strongly associated with infection by human papillomavirus (HPV). Integration of HPV is thought to form a key step in the formation of cancer, and is thought to ...
  • Inhibition of Plk1 and Cyclin B1 expression results in panobinostat-induced G(2) delay and mitotic defects 

    Prystowsky, Michael; Feeney, Katherine; Kawachi, Nicole; Montagna, Cristina; Willmott, Michelle; Wasson, Christopher; Antkowiak, Maciej; Loudig, Olivier; Parish, Joanna (2013-09-12) - Journal article
    The development of clinically useful histone deacetylase inhibitors has expanded greatly. In a preclinical study, we showed that panobinostat (LBH589) inhibits cell cycle progression of human head and neck squamous cell ...