Now showing items 1-3 of 3

  • An internal thioester in a pathogen surface protein mediates covalent host binding 

    Walden, Miriam; Edwards, John Michael; Dziewulska, Aleksandra Malgorzata; Bergmann, Rene; Saalbach, Gerhard; Kan, Su-Yin; Miller, Ona Kealoha; Weckener, Miriam; Jackson, Rosemary J.; Shirran, Sally Lorna; Botting, Catherine Helen; Florence, Gordon John; Rohde, Manfred; Banfield, Mark J.; Schwarz-Linek, Uli (2015) - Journal article
    To cause disease and persist in a host, pathogenic and commensal microbes must adhere to tissues. Colonization and infection depend on specific molecular interactions at the host-microbe interface that involve microbial ...
  • The search for allosteric inhibitors 

    Brear, Paul (University of St Andrews, 2013-06-26) - Thesis
    This thesis describes the development of chemical tools that inhibit the sialidases NanA and NanB from Streptococcus pneumonia. The primary focus was on the discovery of allosteric inhibitors of NanA and NanB, however, ...
  • Structural studies on the sialidases from Streptococcus pneumoniae and Pseudomonas aeruginosa 

    Xu, Guogang (University of St Andrews, 2009) - Thesis
    The sialidases are a group of glycosyl hydrolases that specifically remove terminal sialic acid (Neu5Ac) residues from various glycans. In the two common human pathogenic bacteria Streptococcus pneumoniae and Pseudomonas ...