Now showing items 1-8 of 8

  • Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain 

    Potter, Jane A.; Randall, Richard Edward; Taylor, Garry L. (2008-02-28) - Journal article
    Background: IPS-1/MAVS/VISA/Cardif is an adaptor protein that plays a crucial role in the induction of interferons in response to viral infection. In the initial stage of the intracellular antiviral response two RNA ...
  • Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction 

    Killip, M. J.; Young, D. F.; Gatherer, D.; Ross, C. S.; Short, J. A. L.; Davison, A. J.; Goodbourn, S.; Randall, R. E. (2013-05) - Journal article
    Preparations of parainfluenza virus 5 (PIV5) that are potent activators of the interferon (IFN) induction cascade were generated by high-multiplicity passage in order to accumulate defective interfering virus genomes (DIs). ...
  • Influenza virus activation of the interferon system 

    Killip, M.J.; Fodor, E.; Randall, R.E. (2015) - Journal article
    The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions ...
  • Innate sensing of HIV-infected cells 

    Lepelley, Alice; Louis, Stephanie; Sourisseau, Marion; Law, Helen K. W.; Pothlichet, Julien; Schilte, Clementine; Chaperot, Laurence; Plumas, Joel; Randall, Richard Edward; Si-Tahar, Mustapha; Mammano, Fabrizio; Albert, Matthew L.; Schwartz, Olivier (2011-02) - Journal article
    Cell-free HIV-1 virions are poor stimulators of type I interferon (IFN) production. We examined here how HIV-infected cells are recognized by plasmacytoid dendritic cells (pDCs) and by other cells. We show that infected ...
  • LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA 

    Childs, Kay S.; Randall, Richard E.; Goodbourn, Stephen (2013-05-09) - Journal article
    The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that ...
  • Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist 

    Young, D F; Galiano, M; Lemon, K; Chen, Y-H; Andrejeva, Jelena; Duprex, P; Rima, B K; Randall, Richard Edward (2009-11) - Journal article
    Although the Enders strain of mumps virus (MuV) encodes a functional V protein that acts as an interferon (IFN) antagonist, in multi-cycle growth assays MuV Enders grew poorly in naive ('IFN-competent' Hep2) cells but grew ...
  • The regulation of type I interferon production by paramyxoviruses 

    Goodbourn, S; Randall, Richard Edward (2009-09) - Journal article
    Experimentally, paramyxoviruses are conventionally considered good inducers of type I interferons (IFN-alpha/beta), and have been used as agents in the commercial production of human IFN-alpha. However, in the last few ...
  • RNA interference targets arbovirus replication in Culicoides cells 

    Schnettler, Esther; Ratinier, Maxime; Watson, Mick; Shaw, Andrew E.; McFarlane, Melanie; Varela, Mariana; Elliott, Richard M.; Palmarini, Massimo; Kohl, Alain (2013-03) - Journal article
    Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks, and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral ...