Now showing items 1-2 of 2

  • An evaluation of cognitive deficits in a rat-model of Huntington's disease 

    García Aguirre, Ana I. (University of St Andrews, 2016-06-21) - Thesis
    The purpose of this thesis was to develop methodology by which treatments for the cognitive impairments in Huntington’s disease (HD) could be tested. As such, the thesis focused mainly on evaluating rats with quinolinic ...
  • Mechanistic studies on quinolinate phosphoribosyltransferase 

    Catton, Gemma Rachel (University of St Andrews, 2008-06) - Thesis
    Quinolinate phosphoribosyltransferase (QPRTase, EC 2.4.2.19) is an intriguing enzyme which appears to catalyse two distinct chemical reactions; transfer of a phosphoribosyl moiety from 5-phosphoribosyl-1-pyrophosphate to ...