Now showing items 1-8 of 8

  • Acetylation site specificities of lysine deacetylase inhibitors in human cells 

    Schölz, Christian; Weinert, Brian T.; Wagner, Sebastian A.; Beli, Petra; Miyake, Yasuyuki; Qi, Yun; Jensen, Lars J.; Streicher, Werner; McCarthy, Anna Rose; Westwood, Nicholas James; Lain, Sonya; Cox, Jürgen; Matthias, Patrick; Mann, Matthias; Bradner, James E.; Choudhary, Chunaram (2015) - Journal article
    Lysine deacetylases inhibitors (KDACIs) are used in basic research, and many are being investigated in clinical trials for treatment of cancer and other diseases. However, their specificities in cells are incompletely ...
  • Extensive lysine methylation in hyperthermophilic crenarchaea : potential implications for protein stability and recombinant enzymes 

    Botting, Catherine H.; Talbot, Paul; Paytubi, Sonia; White, Malcolm F. (2010) - Journal article
    In eukarya and bacteria, lysine methylation is relatively rare and is catalysed by sequence-specific lysine methyltransferases that typically have only a single-protein target. Using RNA polymerase purified from the ...
  • The genome of the obligate intracellular parasite Trachipleistophora hominis : new insights into microsporidian genome dynamics and reductive evolution 

    Heinz, Eva; Williams, Tom A.; Nakjang, Sirintra; Noel, Christophe J.; Swan, Daniel C.; Goldberg, Alina V.; Harris, Simon R.; Weinmaier, Thomas; Markert, Stephanie; Becher, Doerte; Bernhardt, Joerg; Dagan, Tal; Hacker, Christian; Lucocq, John Milton; Schweder, Thomas; Rattei, Thomas; Hall, Neil; Hirt, Robert P.; Embley, T. Martin (2012-10-25) - Journal article
    The dynamics of reductive genome evolution for eukaryotes living inside other eukaryotic cells are poorly understood compared to well-studied model systems involving obligate intracellular bacteria. Here we present 8.5 Mb ...
  • Heterogeneity mapping of protein expression in tumors using quantitative immunofluorescence 

    Faratian, Dana; Christiansen, Jason; Gustavson, Mark; Jones, Christine; Scott, Christopher; Um, InHwa; Harrison, David J (2011-10-25) - Journal article
    Morphologic heterogeneity within an individual tumor is well-recognized by histopathologists in surgical practice. While this often takes the form of areas of distinct differentiation into recognized histological subtypes, ...
  • The Scottish Structural Proteomics Facility : targets, methods and outputs 

    Oke, M; Carter, LG; Johnson, KA; Liu, H; McMahon, SA; Yan, X; Kerou, M; Weikart, ND; Kadi, N; Sheikh, MA; Schmelz, S; Dorward, M; Zawadzki, M; Cozens, C; Falconer, H; Powers, H; Overton, IM; van Niekerk, CA; Peng, X; Patel, P; Garrett, RA; Prangishvili, D; Botting, CH; Coote, PJ; Dryden, DT; Barton, GJ; Schwarz-Linek, Uli; Challis, GL; Taylor, GL; White, MF; Naismith, JH (2010-06-01) - Journal article
    The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures ...
  • Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development 

    Fuller, Heidi; Mandefro, Berhan; Shirran, Sally Lorna; Gross, Andrew; Kaus, Anjoscha; Botting, Catherine Helen; Morris, Glen; Sareen, Dhruv (2016-01-11) - Journal article
    Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the ...
  • TarO : a target optimisation system for structural biology 

    Overton, I M; van Niekerk, C A; Carter, L G; Dawson, A; Martin, D M; Cameron, S; McMahon, S A; White, Malcolm F; Hunter, W N; Naismith, Jim; Barton, G J (2008-07) - Journal article
    TarO (http://www.compbio.dundee.ac.uk/taro) offers a single point of reference for key bioinformatics analyses relevant to selecting proteins or domains for study by structural biology techniques. The protein sequence is ...
  • Utilising proteomic approaches to understand oncogenic human herpesviruses (Review) 

    Owen, Christopher B; Hughes, David J; Baquero-Perez, Belinda; Berndt, Anja; Schumann, Sophie; Jackson, Brian R; Whitehouse, Adrian (2014-11) - Journal article
    The γ-herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are successful pathogens, each infecting a large proportion of the human population. These viruses persist for the life of the host and may ...