Now showing items 1-10 of 10

  • Combining synthesis and biosynthesis to generate novel antibiotics 

    Abou Fayad, Antoine (University of St Andrews, 2014-12-01) - Thesis
    This thesis focuses upon pacidamycin, a member of the uridyl peptide antibiotics, a family of antibiotics which exhibit an, as yet, clinically unexploited mode of action, against MraY. The Goss group has previously ...
  • Evolving complex systems from simple molecules 

    Sadownik, Jan (University of St Andrews, 2009) - Thesis
    Until very recently, synthetic chemistry has focussed on the creation of chemical entities with desirable properties through the programmed application of isolated chemical reactions, either individually or in a cascade ...
  • Exploring the scope of organic syntheses with semiconductor photoredox catalysis 

    Manley, David (University of St Andrews, 2014) - Thesis
    Under dry, anaerobic conditions TiO₂ photoredox catalysis has been directed away from oxidative/degradative chemistry. Instead, carboxylic acid photoredox reactions resulted in carbon-carbon bond forming processes. High ...
  • Isothiourea-promoted O- to C-carboxyl transfer reactions 

    Joannesse, Caroline (University of St Andrews, 2011-11-30) - Thesis
    This thesis describes an extensive investigation of the O- to C-carboxyl transfer of oxazolyl carbonates using isothioureas as Lewis base catalysts. The structural requirements of simple bicyclic amidines and isothioureas ...
  • Lewis base organocatalysts for carboxyl and acyl transfer reactions 

    Woods, Philip A. (University of St Andrews, 2011-08-15) - Thesis
    This thesis is concerned with the use of Lewis base organocatalysts for carboxyl and acyl transfer reactions. Chapter 1 introduces the ability of organic Lewis bases other than DMAP-type to promote a range of asymmetric ...
  • Lewis base-promoted organocatalysis : O- to C-carboxyl transfer reactions 

    Campbell, Craig D. (University of St Andrews, 2010-11-30) - Thesis
    This work describes the application of a variety of Lewis bases, encompassing predominantly N-heterocyclic carbenes (NHCs), but also the use of imidazoles, aminopyridines, amidines and isothioureas, as effective catalysts ...
  • Novel catalysts for the hydroxymethylation of allyl alcohol : a convenient synthetic route to 1, 4-butanediol 

    Boogaerts, Ine Ida Françoise (University of St Andrews, 2009-11) - Thesis
    Hydroxymethylation catalysis provides a valuable strategy for the high volume production of alcohols from α-alkenes. Generally this involves a hydroformylation-hydrogenation sequence, but the capacity to optimise selectivity ...
  • Pd catalysed C-C & C-O bond formation using bis-(dialkyl/diarylphosphino)ferrocene ligands 

    Milton, Edward J. (University of St Andrews, 2010-06-23) - Thesis
    A brief introduction explaining phosphine ligand properties, Pd catalysed cross-coupling reactions; the importance of the steps involved in the catalytic cycle (oxidative addition, transmetalation & reductive elimination), ...
  • Synthesis of D-myo-inositol 1,4,5-triphosphate analogues 

    Bello, Davide (University of St Andrews, 2007) - Thesis
    The cytosolic second messenger D-myo-inositol 1,4,5-trisphosphate (InsP₃), has the ability to mobilise Ca²⁺ from intracellular stores. Ca²⁺ controls a wide range of cellular processes, such as cell division and proliferation, ...
  • α,β-unsaturated acyl ammonium intermediates in asymmetric organocatalysis 

    Robinson, Emily R. T. (University of St Andrews, 2015-11-30) - Thesis
    This thesis details investigations into the generation and synthetic utility of α,β-unsaturated acyl ammonium intermediates using isothioureas as Lewis base organocatalysts to generate a range of heterocyclic products. Initial ...