Now showing items 1-11 of 11

  • Advanced techniques in Raman tweezers microspectroscopy for applications in biomedicine 

    Jess, Phillip R.T. (University of St Andrews, 2007-11-30) - Thesis
    This thesis investigates the use of Raman tweezers microspectroscopy to interrogate the biochemistry of single biological cells. Raman tweezers microspectroscopy is a powerful technique, which combines traditional Raman ...
  • Applications of microfluidic chips in optical manipulation & photoporation 

    Marchington, Robert F. (University of St Andrews, 2010-10-01) - Thesis
    Integration and miniaturisation in electronics has undoubtedly revolutionised the modern world. In biotechnology, emerging lab-on-a-chip (LOC) methodologies promise all-integrated laboratory processes, to perform complete ...
  • Applications of microfluidics and optical manipulation for photoporation and imaging 

    Rendall, Helen A. (University of St Andrews, 2015-06-24) - Thesis
    Optical manipulation covers a wide range of techniques to guide and trap cells using only the forces exerted by light. Another optical tool is photoporation, the technique of injecting membrane-impermeable molecules using ...
  • Enhanced optical manipulation of cells using anti-reflection coated microparticles 

    Craig, Derek; McDonald, Alison; Mazilu, Michael; Rendall, Helen Anne; Gunn-Moore, Frank J; Dholakia, Kishan (2015) - Journal article
    We demonstrate the use of anti-reflection (AR) coated microparticles for the enhanced optical manipulation of cells. Specifically, we incubate both CHO-K1 and HL60 cell lines with AR coated titania microparticles and ...
  • Imaging the cellular response to transient shear stress using time-resolved digital holography 

    Arita, Yoshihiko; Antkowiak, Maciej; Gunn-Moore, Frank; Dholakia, Kishan (SPIE, 2014-02-26) - Conference item
    Shear stress has been recognized as one of the biophysical methods by which to permeabilize plasma membranes of cells. In particular, high pressure transient hydrodynamic flows created by laser-induced cavitation have been ...
  • Optical micromanipulation using dispersion-compensated and phase-shaped ultrashort pulsed lasers 

    Shane, Janelle (University of St Andrews, 2009-11-30) - Thesis
    Ultrashort pulsed lasers offer high peak powers at low average powers, making them ideal for maximising the efficiency of nonlinear excitation. Their broad bandwidths make it possible to tailor the pulse's temporal profile ...
  • Optical transfection and injection techniques applied to mammalian and embryonic cells 

    Torres, Maria Leilani (University of St Andrews, 2011-11-30) - Thesis
    The delivery of biomolecules into living cells is an important methodology in cell and molecular biology. Optical methods using lasers are attractive tools for such application. However, the interaction of the laser with ...
  • Optical trapping: optical interferometric metrology and nanophotonics 

    Lee, Woei Ming (University of St Andrews, 2010-06-25) - Thesis
    The two main themes in this thesis are the implementation of interference methods with optically trapped particles for measurements of position and optical phase (optical interferometric metrology) and the optical manipulation ...
  • Photoporation and optical manipulation of plant and mammalian cells 

    Mitchell, Claire A. (University of St Andrews, 2015-06-24) - Thesis
    Optical cell manipulation allows precise and non-invasive exploration of mammalian cell function and physiology for medical applications. Plants, however, represent a vital component of the Earth’s ecosystem and the knowledge ...
  • Plasmonic effects upon optical trapping of metal nanoparticles 

    Dienerowitz, Maria (University of St Andrews, 2010-11-30) - Thesis
    Optical trapping of metal nanoparticles investigates phenomena at the interface of plasmonics and optical micromanipulation. This thesis combines ideas of optical properties of metals originating from solid state physics ...
  • Trapping in a material world 

    Spesyvtseva, Susan; Dholakia, Kishan (2016-05-18) - Journal article
    The ability to manipulate small particles of matter using the forces of light, optical trapping, forms the basis of a number of exciting research areas, spanning fundamental physics, applied chemistry and medicine and ...