Now showing items 1-8 of 8

  • The distribution and physiological roles of nitric oxide in the locomotor circuitry of the mammalian spinal cord 

    Dunford, Catherine (University of St Andrews, 2012-11-30) - Thesis
    The mammalian spinal cord contains the neuronal circuitry necessary to generate rhythmic locomotor activity in the absence of inputs from the higher brain centre or sensory system. This circuitry is regulated by local ...
  • The genetic contribution of the NO system at the glutamatergic post-synapse to schizophrenia : further evidence and meta-analysis 

    Weber, H.; Klamer, D.; Freudenberg, F.; Kittel-Schneider, S.; Rivero, O.; Scholz, C. -J.; Volkert, J.; Kopf, J.; Heupel, J.; Herterich, S.; Adolfsson, R.; Alttoa, A.; Post, A.; Grussendorf, H.; Kramer, A.; Gessner, A.; Schmidt, B.; Hempel, S.; Jacob, C. P.; Sanjuan, J.; Molto, M. D.; Lesch, K. -P.; Freitag, C. M.; Kent, L.; Reif, A. (2014-01) - Journal article
    NO is a pleiotropic signaling molecule and has an important role in cognition and emotion. In the brain, NO is produced by neuronal nitric oxide synthase (NOS-I, encoded by NOS1) coupled to the NMDA receptor via PDZ. ...
  • N-hydroxyguanidines and related compounds as nitric oxide donors 

    Kulczynska, Agnieszka (University of St Andrews, 2009) - Thesis
    The design of new, improved NO-donor drugs is an important pharmacological objective due to the biological importance of nitric oxide. N-Hydroxyguanidines represent a useful class of NO donors where the mechanism of ...
  • New nitric oxide releasing materials 

    McKinlay, Alistair C. (University of St Andrews, 2010-06-23) - Thesis
    The aim of this thesis was to examine the ability of metal organic frameworks (MOFs) to store and controllably release biologically significant amounts of nitric oxide (NO). Initial work involved the synthesis of a series ...
  • Nitric oxide donors for the treatment of prostate cancer 

    Nortcliffe, Andrew (University of St Andrews, 2013-11-29) - Thesis
    Chapter One provides a general introduction into the biology and chemistry of nitric oxide, with particular focus on the role of nitric oxide in cardiovascular disease, cancer and hypoxia. It also details the types of ...
  • Nitric oxide synthase and the contribution of nitric oxide to vertebrate motor control 

    Molinari, Micol Ariella (University of St Andrews, 2008-06) - Thesis
    I have explored the role of nitric oxide (NO) and the distribution of its synthetic enzyme in neurons, nNOS, in vertebrate motor control. The CNS of Xenopus laevis tadpoles was used primarily in this investigation as a ...
  • Nitrosopersulfide (SSNO) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide 

    Cortese-Krott, M.M.; Fernandez, B.O.; Santos, J.L.T.; Mergia, E.; Grman, M.; Nagy, P.; Kelm, M.; Butler, A.; Feelisch, M. (2014-01) - Journal article
    Sulfide salts are known to promote the release of nitric oxide (NO) from S-nitrosothiols and potentiate their vasorelaxant activity, but much of the cross-talk between hydrogen sulfide and NO is believed to occur via ...
  • On the role of NOS1 ex1f-VNTR in ADHD – allelic, subgroup, and meta-analysis 

    Weber, Heike; Kittel-Schneider, S.; Heupel, J; Weißflog, L.; Kent, Lindsey; Freudenberg, F.; Alttoa, A.; Post, A.; Herterich, S.; Haavik, Jan; Halmøy, Anne; Fasmer, Ole Bernt; Landaas, Elisabeth Toverund; Johansson, Stefan; Cormand, Bru; Ribasés, Marta; Sánchez-Mora, Cristina; Ramos-Quiroga, Josep Antoni; Franke, B.; Lesch, K-P.; Reif, Andreas (2015-09) - Journal article
    Attention deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder featuring complex genetics with common and rare variants contributing to disease risk. In a high proportion of cases, ADHD does not ...