Now showing items 1-3 of 3

  • An investigation of NAADP-dependent Ca²⁺ signalling mechanisms in arterial smooth muscle 

    Kinnear, Nicholas P. (University of St Andrews, 2007-11-30) - Thesis
    Previous investigations on pulmonary artery smooth muscle cells have shown that nicotinic acid adenine dinucleotide diphosphate (NAADP) evokes highly localised intracellular Ca²⁺ bursts by mobilising thapsigargin-insensitive ...
  • TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+ 

    Pitt, Samantha Jane; Funnell, Tim M; Sitsapesan, Mano; Venturi, Elisa; Rietdorf, Katja; Ruas, Margarida; Ganesan, A; Gosain, Rajendra; Churchill, Grant C; Zhu, Michael X; Parrington, John; Galione, Antony; Sitsapesan, Rebecca (2010-11-05) - Journal article
    Nicotinic acid adenine dinucleotide phosphate (NAADP) is a molecule capable of initiating the release of intracellular Ca2+ required for many essential cellular processes. Recent evidence links two-pore channels (TPCs) ...
  • Two-pore channels and NAADP-dependent calcium signalling 

    Calcraft, Peter James (University of St Andrews, 2010-06-23) - Thesis
    Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca²⁺ mobilising messenger in mammalian and non-mammalian cells. Studies on a variety of cell types suggest that NAADP evokes Ca²⁺ release from a lysosome-related ...