Now showing items 1-6 of 6

  • Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones 

    Yeh, Pei-Pei; Daniels, David Sydney Bernard; Fallan, Charlene; Gould, Eoin Rory; Simal Fernandez, Carmen; Taylor, James Edward; Slawin, Alexandra Martha Zoya; Smith, Andrew David (2015-02-21) - Journal article
    The exploration and expansion of the scope of the isothiourea-mediated synthesis of dihydropyridinones is presented. The use of ketimines derived from α,β-unsaturated γ-ketoesters as the Michael acceptor in a Michael ...
  • Isothiourea-promoted O- to C-carboxyl transfer reactions 

    Joannesse, Caroline (University of St Andrews, 2011-11-30) - Thesis
    This thesis describes an extensive investigation of the O- to C-carboxyl transfer of oxazolyl carbonates using isothioureas as Lewis base catalysts. The structural requirements of simple bicyclic amidines and isothioureas ...
  • Lewis base-promoted organocatalysis : O- to C-carboxyl transfer reactions 

    Campbell, Craig D. (University of St Andrews, 2010-11-30) - Thesis
    This work describes the application of a variety of Lewis bases, encompassing predominantly N-heterocyclic carbenes (NHCs), but also the use of imidazoles, aminopyridines, amidines and isothioureas, as effective catalysts ...
  • Organocatalytic functionalisation of carboxylic acids using isothioureas 

    Morrill, Louis Christian (University of St Andrews, 2014-06-25) - Thesis
    This thesis describes investigations into the ability of isothioureas to act as organocatalysts in formal [4+2] cycloadditions between carboxylic acids and various Michael acceptors via C1-ammonium enolate intermediates. Initial ...
  • A scalable, chromatography-free synthesis of benzotetramisole 

    Daniels, David Sydney Bernard; Smith, Siobhan Rose; Lebl, Tomas; Shapland, P.; Smith, Andrew David (2015-01) - Journal article
    The scalable, chromatography-free synthesis of the chiral isothiourea benzotetramisole (BTM) in two steps from commercially available materials is presented. A detailed procedure for the synthesis of both enantiomers and ...
  • Stereodivergent organocatalytic intramolecular michael addition/ lactonization for the asymmetric synthesis of substituted dihydrobenzofurans and tetrahydrofurans 

    Belmessieri, D.; De La Houpliere, A.; Calder, E.D.D.; Taylor, J.E.; Smith, A.D. (2014-07-28) - Journal article
    A stereodivergent asymmetric Lewis base catalyzed Michael addition/lactonization of enone acids into substituted dihydrobenzofuran and tetrahydrofuran derivatives is reported. Commercially available (S)-(-)-tetramisole ...