Now showing items 1-3 of 3

  • The AEROPATH project targeting Pseudomonas aeruginosa : crystallographic studies for assessment of potential targets in early-stage drug discovery 

    Moynie, Lucile; Schnell, Robert; McMahon, Stephen A.; Sandalova, Tatyana; Abdelli Boulkeroua, Wassila; Schmidberger, Jason W.; Alphey, Magnus; Cukier, Cyprian; Duthie, Fraser; Kopec, Jolanta; Liu, Huanting; Jacewicz, Agata; Hunter, William N.; Naismith, James H.; Schneider, Gunter (2013-01) - Journal article
    Bacterial infections are increasingly difficult to treat owing to the spread of antibiotic resistance. A major concern is Gram-negative bacteria, for which the discovery of new antimicrobial drugs has been particularly ...
  • The role of silver additives in gold-mediated C-H functionalisation 

    Patrick, Scott R.; Boogaerts, Ine I. F.; Gaillard, Sylvain; Slawin, Alexandra M. Z.; Nolan, Steven P. (2011-07-01) - Journal article
    The role of silver additives is examined in the context of gold-mediated functionalisation of aromatic C-H bonds. Doubt is cast on the commonly cited route of halide abstraction from gold and evidence of substrate activation ...
  • Synthesis of phosphonate and phostone analogues of ribose-1-phosphates 

    Nasomjai, Pitak; O'Hagan, David; Slawin, Alexandra M. Z. (2009-07-27) - Journal article
    The synthesis of phosphonate analogues of ribose-1-phosphate and 5-fluoro-5-deoxyribose-1-phosphate is described. Preparations of both the alpha- and beta-phosphonate anomers are reported for the ribose and 5-fluoro-5-deoxyribose ...