Now showing items 1-7 of 7

  • Acetylation site specificities of lysine deacetylase inhibitors in human cells 

    Schölz, Christian; Weinert, Brian T.; Wagner, Sebastian A.; Beli, Petra; Miyake, Yasuyuki; Qi, Yun; Jensen, Lars J.; Streicher, Werner; McCarthy, Anna Rose; Westwood, Nicholas James; Lain, Sonya; Cox, Jürgen; Matthias, Patrick; Mann, Matthias; Bradner, James E.; Choudhary, Chunaram (2015) - Journal article
    Lysine deacetylases inhibitors (KDACIs) are used in basic research, and many are being investigated in clinical trials for treatment of cancer and other diseases. However, their specificities in cells are incompletely ...
  • Characterisation of Sulfolobus solfataricus Ard1, a promiscuous N-acetyltransferase 

    Mackay, Dale Tara (University of St Andrews, 2008-06-27) - Thesis
    Compaction of DNA into chromatin is an important feature of every living cell. This compaction phenomenon is brought about and maintained by a variety of DNA binding proteins, which have evolved to suit the specific needs ...
  • Dimer-dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba 

    Jelinska, Clare; Petrovic-Stojanovska, Biljana; Ingledew, W John; White, Malcolm F (2010-04-01) - Journal article
    Archaea use a variety of small basic proteins to package their DNA. One of the most widespread and highly conserved is the Alba (Sso10b) protein. Alba interacts with both DNA and RNA in vitro, and we show in the present ...
  • Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator 

    Lain, Sonia; Hollick, Jonathan J.; Campbell, Johanna; Staples, Oliver D.; Higgins, Maureen; Aoubala, Mustapha; McCarthy, Anna; Appleyard, Virginia; Murray, Karen E.; Baker, Lee; Thompson, Alastair; Mathers, Joanne; Holland, Stephen J.; Stark, Michael J. R.; Pass, Georgia; Woods, Julie; Lane, David P.; Westwood, Nicholas J. (2008-05-06) - Journal article
    We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more ...
  • Extensive lysine methylation in hyperthermophilic crenarchaea : potential implications for protein stability and recombinant enzymes 

    Botting, Catherine H.; Talbot, Paul; Paytubi, Sonia; White, Malcolm F. (2010) - Journal article
    In eukarya and bacteria, lysine methylation is relatively rare and is catalysed by sequence-specific lysine methyltransferases that typically have only a single-protein target. Using RNA polymerase purified from the ...
  • The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution 

    Bowman, Andrew; Hammond, Colin M.; Stirling, Andrew; Ward, Richard; Shang, Weifeng; El Mkami, Hassane; Robinson, David A.; Svergun, Dmitri I.; Norman, David G.; Owen-Hughes, Tom (2014) - Journal article
    NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously ...
  • Structure of the CRISPR Interference complex CSM reveals key similarities with Cascade 

    Rouillon, Christophe; Zhou, Min; Zhang, Jing; Argyris, Politis; Beilsten-Edmands, Victoria; Cannone, Guiseppe; Graham, Shirley; Robinson, Carol; Spagnolo, Laura; White, Malcolm F (2013-10-10) - Journal article
    The Clustered Regularly Interspaced Palindromic Repeats (CRISPR) system is an adaptive immune system in prokaryotes. Interference complexes encoded by CRISPR-associated (cas) genes utilize small RNAs for homology-directed ...