Now showing items 1-6 of 6

    • The CRISPR associated protein Cas4 Is a 5' to 3' DNA exonuclease with an iron-sulfur cluster 

      Zhang, Jing; Kasciukovic, Taciana; White, Malcolm F. (2012-10-08) - Journal article
      The Cas4 protein is one of the core CRISPR-associated (Cas) proteins implicated in the prokaryotic CRISPR system for antiviral defence. Cas4 is thought to play a role in the capture of new viral DNA sequences for incorporation ...
    • Hot and crispy : CRISPR-Cas systems in the hyperthermophile Sulfolobus solfataricus 

      Zhang, Jing; White, Malcolm F. (2013-12) - Journal article
      The CRISPR (clustered regularly interspaced short palindromic repeats) and Cas (CRISPR-associated) genes are widely spread in bacteria and archaea, representing an intracellular defence system against invading viruses and ...
    • Multiple nucleic acid cleavage modes in divergent type III CRISPR systems 

      Zhang, Jing; Graham, Shirley; Tello, Agnes; Liu, Huanting; White, Malcolm Frederick (2016-02-29) - Journal article
      CRISPR-Cas is an RNA-guided adaptive immune system that protects bacteria and archaea from invading nucleic acids. Type III systems (Cmr, Csm) have been shown to cleave RNA targets in vitro and some are capable of ...
    • Structure and mechanism of the CMR complex for CRISPR-Mediated antiviral immunity 

      Zhang, Jing; Rouillon, Christophe; Kerou, Melina; Reeks, Judith; Brugger, Kim; Graham, Shirley; Reimann, Julia; Cannone, Giuseppe; Liu, Huanting; Albers, Sonja-Verena; Naismith, James H.; Spagnolo, Laura; White, Malcolm F (2012-02-10) - Journal article
      The prokaryotic clusters of regularly interspaced palindromic repeats (CRISPR) system utilizes genomically encoded CRISPR RNA (crRNA), derived from invading viruses and incorporated into ribonucleoprotein complexes with ...
    • Structure of the CRISPR Interference complex CSM reveals key similarities with Cascade 

      Rouillon, Christophe; Zhou, Min; Zhang, Jing; Argyris, Politis; Beilsten-Edmands, Victoria; Cannone, Guiseppe; Graham, Shirley; Robinson, Carol; Spagnolo, Laura; White, Malcolm F (2013-10-10) - Journal article
      The Clustered Regularly Interspaced Palindromic Repeats (CRISPR) system is an adaptive immune system in prokaryotes. Interference complexes encoded by CRISPR-associated (cas) genes utilize small RNAs for homology-directed ...
    • A type III-B CRISPR–Cas effector complex mediating massive target DNA destruction 

      Han, Wenyuan; Li, Yingjun; Deng, Ling; Feng, Mingxia; Peng, Wenfang; Hallstrøm, Søren; Zhang, Jing; Peng, Nan; Liang, Yun Xiang; White, Malcolm Frederick; She, Qunxin (2017-02-28) - Journal article
      The CRISPR (clustered regularly interspaced short palindromic repeats) system protects archaea and bacteria by eliminating nucleic acid invaders in a crRNA-guided manner. The Sulfolobus islandicus type III-B effector Cmr-α ...