Now showing items 1-6 of 6

    • Burkholderia pseudomallei genome plasticity associated with genomic island variation 

      Tumapa, Sarinna; Holden, Matthew T. G.; Vesaratchavest, Mongkol; Wuthiekanun, Vanaporn; Limmathurotsakul, Direk; Chierakul, Wirongrong; Feil, Edward J.; Currie, Bart J.; Day, Nicholas P. J.; Nierman, William C.; Peacock, Sharon J. (2008-04-25) - Journal article
      Background: Burkholderia pseudomallei is a soil-dwelling saprophyte and the cause of melioidosis. Horizontal gene transfer contributes to the genetic diversity of this pathogen and may be an important determinant of virulence ...
    • Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting 

      Tong, Steven Y C; Holden, Matthew T G; Nickerson, Emma K; Cooper, Ben S; Köser, Claudio U; Cori, Anne; Jombart, Thibaut; Cauchemez, Simon; Fraser, Christophe; Wuthiekanun, Vanaporn; Thaipadungpanit, Janjira; Hongsuwan, Maliwan; Day, Nicholas P; Limmathurotsakul, Direk; Parkhill, Julian; Peacock, Sharon J (2014-12-09) - Journal article
      Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial infection. Whole-genome sequencing of MRSA has been used to define phylogeny and transmission in well-resourced healthcare settings, yet the ...
    • Global and regional dissemination and evolution of Burkholderia pseudomallei 

      Chewapreecha, Claire; Holden, Matthew T. G.; Vehkala, Minna; Välimäki, Niko; Yang, Zhirong; Harris, Simon R.; Mather, Alison E.; Tuanyok, Apichai; De Smet, Birgit; Le Hello, Simon; Bizet, Chantal; Mayo, Mark; Wuthiekanun, Vanaporn; Limmathurotsakul, Direk; Phetsouvanh, Rattanaphone; Spratt, Brian G.; Corander, Jukka; Keim, Paul; Dougan, Gordon; Dance, David A. B.; Currie, Bart J.; Parkhill, Julian; Peacock, Sharon J. (2017-01-23) - Journal article
      The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei ...
    • High Rates of Homologous Recombination in the Mite Endosymbiont and Opportunistic Human Pathogen Orientia tsutsugamushi 

      Sonthayanon, Piengchan; Peacock, Sharon J.; Chierakul, Wirongrong; Wuthiekanun, Vanaporn; Blacksell, Stuart D.; Holden, Mathew T. G.; Bentley, Stephen D.; Feil, Edward J.; Day, Nicholas P. J.; Holden, Matthew (2010-07) - Journal article
      Orientia tsutsugamushi is an intracellular alpha-proteobacterium which resides in trombiculid mites, and is the causative agent of scrub typhus in East Asia. The genome sequence of this species has revealed an unprecedented ...
    • A Single Multilocus Sequence Typing (MLST) scheme for seven pathogenic Leptospira Species 

      Boonsilp, Siriphan; Thaipadungpanit, Janjira; Amornchai, Premjit; Wuthiekanun, Vanaporn; Bailey, Mark S.; Holden, Matthew; Zhang, Cuicai; Jiang, Xiugao; Koizumi, Nobuo; Taylor, Kyle; Galloway, Renee; Hoffmaster, Alex R.; Craig, Scott; Smythe, Lee D.; Hartskeerl, Rudy A.; Day, Nicholas P.; Chantratita, Narisara; Feil, Edward J.; Aanensen, David M.; Spratt, Brian G.; Peacock, Sharon J. (2013-01) - Journal article
      Background: The available Leptospira multilocus sequence typing (MLST) scheme supported by a MLST website is limited to L. interrogans and L. kirschneri. Our aim was to broaden the utility of this scheme to incorporate a ...
    • T cell immunity to the alkyl hydroperoxide reductase of Burkholderia pseudomallei : a correlate of disease outcome in acute melioidosis 

      Reynolds, Catherine; Goudet, Amélie; Jenjaroen, Kemajittra; Sumonwiriya, Manutsanun; Rinchai, Darawan; Musson, Julie; Overbeek, Saskia; Makinde, Julia; Quigley, Kathryn; Manji, Jiten; Spink, Natasha; Yos, Pagnarith; Wuthiekanun, Vanaporn; Bancroft, Gregory; Robinson, John; Lertmemongkolchai, Ganjana; Dunachie, Susanna; Maillere, Bernard; Holden, Matthew; Altmann, Daniel; Boyton, Rosemary (2015-05-15) - Journal article
      There is an urgent need for a better understanding of adaptive immunity to Burkholderia pseudomallei, the causative agent of melioidosis that is frequently associated with sepsis or death in patients in Southeast Asia and ...