Now showing items 1-3 of 3

  • Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data 

    Camacho, Niedzica; Van Loo, Peter; Edwards, Sandra; Kay, Jonathan D.; Matthews, Lucy; Haase, Kerstin; Clark, Jeremy; Dennis, Nening; Thomas, Sarah; Kremeyer, Barbara; Zamora, Jorge; Butler, Adam P.; Gundem, Gunes; Merson, Sue; Luxton, Hayley; Hawkins, Steve; Ghori, Mohammed; Marsden, Luke; Lambert, Adam; Karaszi, Katalin; Pelvender, Gill; Massie, Charlie E.; Kote-Jarai, ZSofia; Raine, Keiran; Jones, David; Howat, William J.; Hazell, Steven; Livni, Naomi; Fisher, Cyril; Ogden, Christopher; Kumar, Pardeep; Thompson, Alan; Nicol, David; Mayer, Erik; Dudderidge, Tim; Yu, Yongwei; Zhang, Hongwei; Shah, Nimish C.; Gnanapragasam, Vincent J.; Group, The CRUK-ICGC Prostate; Isaacs, William; Visakorpi, Tapio; Hamdy, Freddie; Berney, Dan; Verrill, Clare; Warren, Anne Y.; Wedge, David C.; Lynch, Andrew G.; Foster, Christopher S.; Lu, Yong Jie; Bova, G. Steven; Whitaker, Hayley C.; McDermott, Ultan; Neal, David E.; Eeles, Rosalind; Cooper, Colin S.; Brewer, Daniel S. (2017-09-25) - Journal article
    A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively ...
  • Genomic evolution of breast cancer metastasis and relapse 

    Yates, Lucy R.; Knappskog, Stian; Wedge, David; Farmery, James H. R.; Gonzalez, Santiago; Martincorena, Inigo; Alexandrov, Ludmil B.; Van Loo, Peter; Haugland, Hans Kristian; Lilleng, Peer Kaare; Gundem, Gunes; Gerstung, Moritz; Pappaemmanuil, Elli; Gazinska, Patrycja; Bhosle, Shriram G; Jones, David; Raine, Keiran; Mudie, Laura; Latimer, Calli; Sawyer, Elinor; Desmedt, Christine; Sotiriou, Christos; Stratton, Michael R.; Sieuwerts, Anieta M.; Lynch, Andy G.; Martens, John W.; Richardson, Andrea L.; Tutt, Andrew; Lønning, Per Eystein; Campbell, Peter J. (2017-08-14) - Journal article
    Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel ...
  • Mutational signatures of ionizing radiation in second malignancies 

    Behjati, Sam; Gundem, Gunes; Wedge, David C.; Roberts, Nicola D.; Tarpey, Patrick S.; Cooke, Susanna L.; Van Loo, Peter; Alexandrov, Ludmil B.; Ramakrishna, Manasa; Davies, Helen; Nik-Zainal, Serena; Hardy, Claire; Latimer, Calli; Raine, Keiran M.; Stebbings, Lucy; Menzies, Andy; Jones, David; Shepherd, Rebecca; Butler, Adam P.; Teague, Jon W.; Jorgensen, Mette; Khatri, Bhavisha; Pillay, Nischalan; Shlien, Adam; Futreal, P. Andrew; Badie, Christophe; McDermott, Ultan; Bova, G. Steven; Richardson, Andrea L.; Flanagan, Adrienne M.; Stratton, Michael R.; Campbell, Peter J.; Lynch, Andrew G. (2016-09-12) - Journal article
    Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched ...