Now showing items 1-2 of 2

    • Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells 

      Meehan, James; Ward, Carol; Turnbull, Arran; Bukowski-Wills, Jimi; Finch, Andrew; Jarman, Edward J.; Xintaropoulou, Chrysi; Martinez-Perez, Carlos; Gray, Mark; Pearson, Matthew; Mullen, Peter; Supuran, Claudia T.; Carta, Fabrizio; Harrison, David James; Kunkler, Ian H.; Langdon, Simon (2017) - Journal article
      Hypoxic cancer cells exhibit resistance to many therapies. This study compared the therapeutic effect of targeting the pH regulatory proteins (CAIX, NHE1 and V-ATPase) that permit cancer cells to adapt to hypoxic conditions, ...
    • Novel histopathologic feature identified through image analysis augments stage II colorectal cancer clinical reporting 

      Caie, Peter David; Zhou, Ying; Turnbull, Arran; Oniscu, Anca; Harrison, David James (2016-06-15) - Journal article
      A number of candidate histopathologic factors show promise in identifying stage II colorectal cancer (CRC) patients at a high risk of disease-specific death, however they can suffer from low reproducibility and none have ...