Now showing items 1-9 of 9

    • Common variants in left/right asymmetry genes and pathways are associated with relative hand skill 

      Brandler, William; Morris, Andrew; Evans, David; Scerri, Thomas; Kemp, John; Timpson, Nicholas; St Pourcain, Beate; Davey Smith, George; Ring, Susan; Stein, John; Monaco, Anthony; Talcott, Joel; Fisher, Simon; Webber, Caleb; Paracchini, Silvia (2013-09-12) - Journal article
      Humans display structural and functional asymmetries in brain organization, strikingly with respect to language and handedness. The molecular basis of these asymmetries is unknown. We report a genome-wide association study ...
    • The DCDC2 deletion is not a risk factor for dyslexia 

      Scerri, Thomas S.; Macpherson, Ellen; Martinelli, Angela; Wa, Wong Cheuk; Monaco, Anthony P.; Stein, John; Zheng, Mo; Ho, Connie Suk-Han; McBride, Catherine; Snowling, Margaret; Hulme, Charles; Hayiou-Thomas, Marianna E.; Waye, Mary M. Y.; Talcott, Joel B.; Paracchini, Silvia (2017-07-25) - Journal article
      Dyslexia is a specific impairment in learning to read and has strong heritability. An intronic deletion within the DCDC2 gene, with ~8% frequency in European populations, is increasingly used as a marker for dyslexia in ...
    • The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure 

      Scerri, Thomas S.; Darki, Fahimeh; Newbury, Dianne F.; Whitehouse, Andrew J. O.; Peyrard-Janvid, Myriam; Matsson, Hans; Ang, Qi W.; Pennell, Craig E.; Ring, Susan; Stein, John; Morris, Andrew P.; Monaco, Anthony P.; Kere, Juha; Talcott, Joel B.; Klingberg, Torkel; Paracchini, Silvia (2012-11-28) - Journal article
      Independent studies have shown that candidate genes for dyslexia and specific language impairment (SLI) impact upon reading/language-specific traits in the general population. To further explore the effect of disorder-associated ...
    • Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes 

      Pettigrew, Kerry Andrea; Frinton, Emily; Nudel, Ron; Chan, May T. M.; Thompson, Paul; Hayiou-Thomas, Marianna E.; Talcott, Joel B.; Stein, John; Monaco, Anthony P.; Hulme, Charles; Snowling, Margaret J.; Newbury, Diane F.; Paracchini, Silvia (2016-06-14) - Journal article
      Background: Specific Language Impairment (SLI) is a common neurodevelopmental disorder, observed in 5-10% of children. Family and twin studies suggest a strong genetic component, but relatively few candidate genes have ...
    • Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort 

      Becker, Jessica; Czamara, Darina; Scerri, Tom S; Ramus, Franck; Csépe, Valéria; Talcott, Joel B; Stein, John; Morris, Andrew; Ludwig, Kerstin U; Hoffmann, Per; Honbolygó, Ferenc; Tóth, Dénes; Fauchereau, Fabien; Bogliotti, Caroline; Iannuzzi, Stéphanie; Chaix, Yves; Valdois, Sylviane; Billard, Catherine; George, Florence; Soares-Boucaud, Isabelle; Gérard, Christophe-Loïc; van der Mark, Sanne; Schulz, Enrico; Vaessen, Anniek; Maurer, Urs; Lohvansuu, Kaisa; Lyytinen, Heikki; Zucchelli, Marco; Brandeis, Daniel; Blomert, Leo; Leppänen, Paavo Ht; Bruder, Jennifer; Monaco, Anthony P; Müller-Myhsok, Bertram; Kere, Juha; Landerl, Karin; Nöthen, Markus M; Schulte-Körne, Gerd; Paracchini, Silvia; Peyrard-Janvid, Myriam; Schumacher, Johannes (2014-05) - Journal article
      Dyslexia is one of the most common childhood disorders with a prevalence of around 5-10% in school-age children. Although an important genetic component is known to have a role in the aetiology of dyslexia, we are far from ...
    • The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts 

      Shore, Robert Joseph; Covill, Laura; Pettigrew, Kerry Andrea; Brandler, William A.; Diaz Vazquez, Rebeca; Xu, Yiwang; Tello, Javier; Talcott, Joel B.; Newbury, Dianne F.; Stein, John; Monaco, Anthony P.; Paracchini, Silvia (2016-05-01) - Journal article
      We recently reported the association of the PCSK6 gene with handedness through a quantitative genome-wide association study (GWAS; P < 0.5 x 10-8) for a relative hand skill measure in individuals with dyslexia. PCSK6 ...
    • Identification of candidate genes for dyslexia susceptibility on chromosome 18 

      Scerri, Thomas S.; Paracchini, Silvia; Morris, Andrew; MacPhie, I. Laurence; Talcott, Joel; Stein, John; Smith, Shelley D.; Pennington, Bruce F.; Olson, Richard K.; DeFries, John C.; Monaco, Anthony P. (2010-10-28) - Journal article
      Background: Six independent studies have identified linkage to chromosome 18 for developmental dyslexia or general reading ability. Until now, no candidate genes have been identified to explain this linkage. Here, we set ...
    • Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia 

      Simpson, Nuala H; Addis, Laura; Brandler, William M; Slonims, Vicky; Clark, Ann; Watson, Jocelynne; Scerri, Thomas S; Hennessy, Elizabeth R; Bolton, Patrick F; Conti-Ramsden, Gina; Fairfax, Benjamin P; Knight, Julian C; Stein, John; Talcott, Joel B; O'Hare, Anne; Baird, Gillian; Paracchini, Silvia; Fisher, Simon E; Newbury, Dianne F; Consortium, Sli (2014-04) - Journal article
      Sex chromosome aneuploidies increase the risk of spoken or written language disorders but individuals with specific language impairment (SLI) or dyslexia do not routinely undergo cytogenetic analysis. We assess the frequency ...
    • PCSK6 is associated with handedness in individuals with dyslexia 

      Scerri, Thomas S.; Brandler, William M.; Paracchini, Silvia; Morris, Andrew P.; Ring, Susan M.; Richardson, Alex J.; Talcott, Joel B.; Stein, John; Monaco, Anthony P. (2011-02) - Journal article
      Approximately 90% of humans are right-handed. Handedness is a heritable trait, yet the genetic basis is not well understood. Here we report a genome-wide association study for a quantitative measure of relative hand skill ...