Now showing items 1-2 of 2

    • The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1 : implications to protein function and drug design 

      Ronin, Céline; Costa, David Mendes; Tavares, Joana; Faria, Joana; Ciesielski, Fabrice; Ciapetti, Paola; Smith, Terry K.; MacDougall, Jane; Cordeiro-da-Silva, Anabela; Pemberton, Iain K. (2018-03-15) - Journal article
      The de novo crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1 (LiSir2rp1) has been solved at 1.99Å in complex with an acetyl-lysine peptide substrate. The structure is broadly ...
    • Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease 

      Gaspar, Luís; Coron, Ross P.; Kongthoo Lin, Paul; Costa, David M.; Perez-Cabezas, Begoña; Tavares, Joana; Roura-Ferrer, Meritxell; Ramos, Isbaal; Ronin, Céline; Major, Louise L.; Ciesielski, Fabrice; Pemberton, Iain K.; MacDougall, Jane; Ciapetti, Paola; Smith, Terry K.; Cordeiro-da-Silva, Anabela (2018-01-22) - Journal article
      Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region’s ...