Now showing items 1-3 of 3

    • Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates 

      Melo Czekster, Clarissa; Ludewig, Hannes; McMahon, Stephen A.; Naismith, James H. (2017-10-19) - Journal article
      Peptide macrocycles are promising therapeutic molecules because they are protease resistant, structurally rigid, membrane permeable and capable of modulating protein-protein interactions. Here, we report the characterization ...
    • Mechanisms of cyanobactin biosynthesis 

      Melo Czekster, Clarissa; Ge, Ying; Naismith, James H. (2016-12) - Journal item
      Cyanobactins are a diverse collection of natural products that originate from short peptides made on a ribosome. The amino acids are modified in a series of transformations catalyzed by multiple enzymes. The patellamide ...
    • The rhizoferrin biosynthetic gene in the fungal pathogen Rhizopus delemar is a novel member of the NIS gene family 

      Carroll, Cassandra S.; Grieve, Clark L.; Murugathasan, Indu; Bennet, Andrew J.; Melo Czekster, Clarissa; Lui, Huanting; Naismith, James; Moore, Margo M. (2017-08) - Journal article
      Iron is essential for growth and in low iron environments such as serum many bacteria and fungi secrete ferric iron-chelating molecules called siderophores. All fungi produce hydroxamate siderophores with the exception of ...