Now showing items 1-3 of 3

    • Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models 

      Koussounadis, Antonis; Langdon, Simon; Um, In Hwa; Kay, Charlene; Francis, Kyle; Harrison, David James; Smith, V Anne (2016-03-10) - Journal article
      Background: The dynamic changes that occur in protein expression after treatment of a cancer in vivo are poorly described. In this study we measure the effect of chemotherapy over time on the expression of a panel of ...
    • Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells 

      Meehan, James; Ward, Carol; Turnbull, Arran; Bukowski-Wills, Jimi; Finch, Andrew; Jarman, Edward J.; Xintaropoulou, Chrysi; Martinez-Perez, Carlos; Gray, Mark; Pearson, Matthew; Mullen, Peter; Supuran, Claudia T.; Carta, Fabrizio; Harrison, David James; Kunkler, Ian H.; Langdon, Simon (2017) - Journal article
      Hypoxic cancer cells exhibit resistance to many therapies. This study compared the therapeutic effect of targeting the pH regulatory proteins (CAIX, NHE1 and V-ATPase) that permit cancer cells to adapt to hypoxic conditions, ...
    • Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system 

      Koussounadis, Antonis; Langdon, Simon; Um, In Hwa; Harrison, David James; Smith, V Anne (2015-06-08) - Journal article
      Differential mRNA expression studies implicitly assume that changes in mRNA expression have biological meaning, most likely mediated by corresponding changes in protein levels. Yet studies into mRNA-protein correspondence ...