Now showing items 1-4 of 4

    • The cyanobactin heterocyclase enzyme : A processive adenylase that operates with a defined order of reaction 

      Koehnke, Jesko Alexander Johannes Gunter; Bent, Andrew Frank; Zollman, David; Smith, Kieran; Houssen, Wael E.; Zhu, Xiaofeng; Mann, Greg; Lebl, Tomas; Scharff, Richard; Shirran, Sally Lorna; Botting, Catherine Helen; Jaspers, Marcel; Schwarz-Linek, Uli; Naismith, Jim (2013-12) - Journal article
    • Structural analysis of leader peptide binding enables leader-free cyanobactin processing 

      Koehnke, Jesko Alexander Johannes Gunter; Mann, Greg; Bent, Andrew Frank; Ludewig, Hannes; Shirran, Sally Lorna; Botting, Catherine Helen; Lebl, Tomas; Houssen, Wael; Jaspers, Marcel; Naismith, Jim (2015-08) - Journal article
      Regioselective modification of amino acids within the context of a peptide is common to a number of biosynthetic pathways and many such products have potential as therapeutics. The ATP dependent enzyme LynD heterocyclizes ...
    • The structural biology of patellamide biosynthesis 

      Koehnke, Jesko Alexander Johannes Gunter; Bent, Andrew Frank; Houssen, Wael E.; Mann, Greg; Jaspars, Marcel; Naismith, Jim (2014-12) - Journal article
      The biosynthetic pathways for patellamide and related natural products have recently been studied by structural biology. These pathways produce molecules that have a complex framework and exhibit a diverse array of activity ...
    • The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster 

      Mann, Greg; Koehnke, Jesko Alexander Johannes Gunter; Bent, Andrew Frank; Graham, Rachael; Houssen, Wael; Jaspars, Marcel; Schwarz-Linek, Uli; Naismith, Jim (2014-12) - Journal article
      Patellamides are members of the cyanobactin family of ribosomally synthesized and post-translationally modified cyclic peptide natural products, many of which, including some patellamides, are biologically active. A detailed ...