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    • Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns 

      Sproul, Duncan; Kitchen, Robert R; Nestor, Colm E; Dixon, J Michael; Sims, Andrew H; Harrison, David J; Ramsahoye, Bernard H; Meehan, Richard R (2012-10-03) - Journal article
      ABSTRACT: BACKGROUND: Aberrant CpG island promoter DNA hypermethylation is frequently observed in cancer and is believed to contribute to tumor progression by silencing the expression of tumor suppressor genes. Previously, ...