Now showing items 1-9 of 9

  • Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission 

    Paterson, Gavin K; Harrison, Ewan M; Murray, Gemma G R; Welch, John J; Warland, James H; Holden, Matthew T G; Morgan, Fiona J E; Ba, Xiaoliang; Koop, Gerrit; Harris, Simon R; Maskell, Duncan J; Peacock, Sharon J; Herrtage, Michael E; Parkhill, Julian; Holmes, Mark A (2015-03-27) - Journal article
    Genome sequencing is revolutionizing clinical microbiology and our understanding of infectious diseases. Previous studies have largely relied on the sequencing of a single isolate from each individual. However, it is not ...
  • The Ess/Type VII secretion system of Staphylococcus aureus shows unexpected genetic diversity 

    Warne, Ben; Harkins, Catriona P; Harris, Simon R; Vatsiou, Alexandra; Stanley-Wall, Nicola; Parkhill, Julian; Peacock, Sharon J; Palmer, Tracy; Holden, Matthew T G (2016-03-13) - Journal article
    BACKGROUND: Type VII protein secretion (T7SS) is a specialised system for excreting extracellular proteins across bacterial cell membranes and has been associated with virulence in Staphylococcus aureus. The genetic diversity ...
  • Evolutionary dynamics of methicillin-resistant Staphylococcus aureus within a healthcare system 

    Hsu, Li-Yang; Harris, Simon R; Chlebowicz, Monika A; Lindsay, Jodi A; Koh, Tse-Hsien; Krishnan, Prabha; Tan, Thean-Yen; Hon, Pei-Yun; Grubb, Warren B; Bentley, Stephen D; Parkhill, Julian; Peacock, Sharon J; Holden, Matthew Tg (2015-04-23) - Journal article
    Background In the past decade, several countries have seen gradual replacement of endemic multi-resistant healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) with clones that are more susceptible to ...
  • Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection 

    Harris, Simon R; Robinson, Carl; Steward, Karen F; Webb, Katy S; Paillot, Romain; Parkhill, Julian; Holden, Matthew T G; Waller, Andrew S (2015-09) - Journal article
    Strangles, the most frequently diagnosed infectious disease of horses worldwide, is caused by Streptococcus equi. Despite its prevalence, the global diversity and mechanisms underlying the evolution of S. equi as a ...
  • Genomic investigations unmask Mycoplasma amphoriforme, a new respiratory pathogen 

    Gillespie, Stephen H; Ling, Clare L; Oravcova, Katarina; Pinheiro, Miguel; Wells, Louise; Bryant, Josephine M; McHugh, Timothy D; Bébéar, Cecile; Webster, David; Harris, Simon R; Seth-Smith, Helena M B; Thomson, Nicholas R (2015-02-01) - Journal article
    Background. Mycoplasma amphoriforme has been associated with infection in patients with Primary Antibody Deficiency (PAD). Little is known about the natural history of infection with this organism and its ability to be ...
  • PinR mediates the generation of reversible population diversity in Streptococcus zooepidemicus 

    Steward, Karen Frances; Harrison, Tihana; Robinson, Carl; Slater, Josh; Maskell, Duncan J; Harris, Simon R; Holden, Matthew T G; Waller, Andrew S (2015-05) - Journal article
    Opportunistic pathogens must adapt to and survive in a wide range of complex ecosystems. Streptococcus zooepidemicus is an opportunistic pathogen of horses and many other animals, including man. The assembly of different ...
  • A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals 

    Harrison, Ewan M; Weinert, Lucy A; Holden, Matthew T G; Welch, John J; Wilson, Katherine; Morgan, Fiona J E; Harris, Simon R; Loeffler, Anette; Boag, Amanda K; Peacock, Sharon J; Paterson, Gavin K; Waller, Andrew S; Parkhill, Julian; Holmes, Mark A (2014-05-13) - Journal article
    Methicillin-resistant Staphylococcus aureus (MRSA) is a global human health problem causing infections in both hospitals and the community. Companion animals, such as cats, dogs, and horses, are also frequently colonized ...
  • Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus 

    Steinig, Eike J; Andersson, Patiyan; Harris, Simon R; Sarovich, Derek S; Manoharan, Anand; Coupland, Paul; Holden, Matthew Tg; Parkhill, Julian; Bentley, Stephen D; Robinson, D Ashley; Tong, Steven Yc (2015-05-16) - Journal article
    Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-associated infection, but there is growing awareness of the emergence of multidrug-resistant lineages in community settings around the world. ...
  • Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis : a retrospective observational study 

    Bryant, Josephine M; Harris, Simon R; Parkhill, Julian; Dawson, Rodney; Diacon, Andreas; van Helden, Paul; Pym, Alex; Ahmad Mahayiddin, Aziah; Chuchottaworn, C; Sanne, Ian M; Louw, Cheryl; Boeree, Martin J; Hoelscher, Michael; McHugh, Timothy D; Bateson, Anna L C; Hunt, Robert D; Mwaigwisya, Solomon; Wright, Laura; Gillespie, Stephen Henry; Bentley, Stephen D (2013-12) - Journal article