Now showing items 1-4 of 4

    • Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase 

      Alphey, Magnus Stephen; Fisher, Gemma; Ge, Ying; Gould, Eoin Rory; Guerreiro Machado, Teresa Filipa; Liu, Huanting; Florence, Gordon John; Naismith, James Henderson; da Silva, Rafael G (2018-05-11) - Journal article
      Allosteric modulation of catalysis is a common regulatory strategy of flux-controlling biosynthetic enzymes. The enzyme ATP phosphoribosyltransferase (ATPPRT) catalyzes the first reaction in histidine biosynthesis, the ...
    • Insights into the mechanism of the cyanobactin heterocyclase enzyme 

      Ge, Ying; Czekster, Clarissa Melo; Miller, Ona K.; Botting, Catherine H.; Schwarz-Linek, Ulrich; Naismith, James H. (2019-04-23) - Journal article
      Cyanobactin heterocyclases share the same catalytic domain (YcaO) as heterocyclases/cyclodehydratases from other ribosomal peptide (RiPPs) biosynthetic pathways. These enzymes process multiple residues (Cys/Thr/Ser) within ...
    • Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase 

      Stroek, Rozanne; Ge, Ying; Talbot, P. D.; Glok, M. K.; Bernas, K. E.; Thomson, Catherine M.; Gould, Eoin R.; Alphey, Magnus S.; Liu, Huanting; Florence, Gordon J.; Naismith, James H.; da Silva, R. G. (2017-02-07) - Journal article
      Adenosine 5′-triphosphate phosphoribosyltransferase (ATPPRT) catalyzes the first step in histidine biosynthesis, the condensation of ATP and 5-phospho-α-d-ribosyl-1-pyrophosphate to generate N1-(5-phospho-β-d-ribosyl)-ATP ...
    • Mechanisms of cyanobactin biosynthesis 

      Melo Czekster, Clarissa; Ge, Ying; Naismith, James H. (2016-12) - Journal item
      Cyanobactins are a diverse collection of natural products that originate from short peptides made on a ribosome. The amino acids are modified in a series of transformations catalyzed by multiple enzymes. The patellamide ...