Now showing items 1-3 of 3

  • Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data 

    Camacho, Niedzica; Van Loo, Peter; Edwards, Sandra; Kay, Jonathan D.; Matthews, Lucy; Haase, Kerstin; Clark, Jeremy; Dennis, Nening; Thomas, Sarah; Kremeyer, Barbara; Zamora, Jorge; Butler, Adam P.; Gundem, Gunes; Merson, Sue; Luxton, Hayley; Hawkins, Steve; Ghori, Mohammed; Marsden, Luke; Lambert, Adam; Karaszi, Katalin; Pelvender, Gill; Massie, Charlie E.; Kote-Jarai, ZSofia; Raine, Keiran; Jones, David; Howat, William J.; Hazell, Steven; Livni, Naomi; Fisher, Cyril; Ogden, Christopher; Kumar, Pardeep; Thompson, Alan; Nicol, David; Mayer, Erik; Dudderidge, Tim; Yu, Yongwei; Zhang, Hongwei; Shah, Nimish C.; Gnanapragasam, Vincent J.; Group, The CRUK-ICGC Prostate; Isaacs, William; Visakorpi, Tapio; Hamdy, Freddie; Berney, Dan; Verrill, Clare; Warren, Anne Y.; Wedge, David C.; Lynch, Andrew G.; Foster, Christopher S.; Lu, Yong Jie; Bova, G. Steven; Whitaker, Hayley C.; McDermott, Ultan; Neal, David E.; Eeles, Rosalind; Cooper, Colin S.; Brewer, Daniel S. (2017-09-25) - Journal article
    A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively ...
  • DESNT : a poor prognosis category of human prostate cancer 

    Luca, Bogdan-Alexandru; Brewer, Daniel S.; Edwards, Dylan R.; Edwards, Sandra; Whitaker, Hayley C.; Merson, Sue; Dennis, Nening; Cooper, Rosalin A.; Hazell, Steven; Warren, Anne Y.; Eeles, Rosalind; Lynch, Andy G.; Ross-Adams, Helen; Lamb, Alastair D.; Neal, David E.; Sethia, Krishna; Mills, Robert D.; Ball, Richard Y.; Curley, Helen; Clark, Jeremy; Moulton, Vincent; Cooper, Colin S. (2017-03-06) - Journal article
    Background : A critical problem in the clinical management of prostate cancer is that it is highly heterogeneous. Accurate prediction of individual cancer behaviour is therefore not achievable at the time of diagnosis ...
  • HES5 silencing is an early and recurrent change in prostate tumourigenesis 

    Massie, Charles E.; Spiteri, Inmaculada; Ross-Adams, Helen; Luxton, Hayley; Kay, Jonathan; Whitaker, Hayley C.; Dunning, Mark J.; Lamb, Alastair D.; Ramos-Montoya, Antonio; Brewer, Daniel S.; Cooper, Colin S.; Eeles, Rosalind; Warren, Anne Y.; Tavaré, Simon; Neal, David E.; Lynch, Andy G.; UK Prostate ICGC Group (2015-04-01) - Journal article
    Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent ...