Now showing items 1-4 of 4

    • Axonal localization of integrins in the CNS is neuronal type and age dependent 

      Andrews, Melissa Renee; Soleman, Sara; Cheah, Menghon; Tumbarello, David; Mason, Matthew; Moloney, Elizabeth; Verhaagen, Joost; Bensadoun, Jean-Charles; Schneider, Bernard; Aebischer, Patrick; Fawcett, James (2016-07) - Journal article
      The regenerative ability of CNS axons decreases with age however this ability remains largely intact in PNS axons throughout adulthood. These differences are likely to correspond with age-related silencing of proteins ...
    • Expression of an activated integrin promotes long-distance sensory axon regeneration in the spinal cord 

      Cheah, Menghon; Andrews, Melissa Renee; Chew, Daniel; Moloney, Elizabeth; Verhaagen, Joost; Fassler, Reinhard; Fawcett, James (2016-07-06) - Journal article
      After CNS injury, axon regeneration is blocked by an inhibitory environment consisting of the highly upregulated tenascin-C and chondroitin sulfate proteoglycans (CSPGs). Tenascin-C promotes growth of axons if they express ...
    • Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons 

      Kappagantula, Sunil; Andrews, Melissa Renee; Cheah, Menghon; Abad-Rodriguez, Jose'; Dotti, Carlos G; Fawcett, James W (2014-02-12) - Journal article
      PNS axons have a high intrinsic regenerative ability, whereas most CNS axons show little regenerative response. We show that activation of Neu3 sialidase, also known as Neuraminidase-3, causing conversion of GD1a and GT1b ...
    • Targeting cell surface receptors for axon regeneration in the central nervous system 

      Cheah, Menghon; Andrews, Melissa R. (2017-01-05) - Journal item
      Axon regeneration in the CNS is largely unsuccessful due to excess inhibitory extrinsic factors within lesion sites together with an intrinsic inability of neurons to regrow following injury. Recent work demonstrates that ...