Now showing items 48-67 of 104

  • Genomic evolution of breast cancer metastasis and relapse 

    Yates, Lucy R.; Knappskog, Stian; Wedge, David; Farmery, James H. R.; Gonzalez, Santiago; Martincorena, Inigo; Alexandrov, Ludmil B.; Van Loo, Peter; Haugland, Hans Kristian; Lilleng, Peer Kaare; Gundem, Gunes; Gerstung, Moritz; Pappaemmanuil, Elli; Gazinska, Patrycja; Bhosle, Shriram G; Jones, David; Raine, Keiran; Mudie, Laura; Latimer, Calli; Sawyer, Elinor; Desmedt, Christine; Sotiriou, Christos; Stratton, Michael R.; Sieuwerts, Anieta M.; Lynch, Andy G.; Martens, John W.; Richardson, Andrea L.; Tutt, Andrew; Lønning, Per Eystein; Campbell, Peter J. (2017-08-14) - Journal article
    Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel ...
  • Global analysis of cetacean line-transect surveys : detecting trends in cetacean density 

    Jewell, Rebecca Lucy; Thomas, Len; Harris, Catriona M; Kaschner, Kristin; Wiff, Rodrigo Alexis; Hammond, Philip Steven; Quick, Nicola Jane (2012-05-07) - Journal article
    Measuring the effect of anthropogenic change on cetacean populations is hampered by our lack of understanding about population status and a lack of power in the available data to detect trends in abundance. Often long-term ...
  • Guessing games on triangle-free graphs 

    Cameron, Peter Jephson; Dang, Anh; Riis, Soren (2016) - Journal article
    The guessing game introduced by Riis is a variant of the "guessing your own hats" game and can be played on any simple directed graph G on n vertices. For each digraph G, it is proved that there exists a unique guessing ...
  • Habitat complexity in aquatic microcosms affects processes driven by detrivores 

    Flores, Lorea; Bailey, R. A.; Elosegi, Arturo; Larrañaga, Aitor; Reiss, Julia (2016-11-01) - Journal article
    Habitat complexity can influence predation rates (e.g. by providing refuge) but other ecosystem processes and species interactions might also be modulated by the properties of habitat structure. Here, we focussed on how ...
  • HES5 silencing is an early and recurrent change in prostate tumourigenesis 

    Massie, Charles E.; Spiteri, Inmaculada; Ross-Adams, Helen; Luxton, Hayley; Kay, Jonathan; Whitaker, Hayley C.; Dunning, Mark J.; Lamb, Alastair D.; Ramos-Montoya, Antonio; Brewer, Daniel S.; Cooper, Colin S.; Eeles, Rosalind; Warren, Anne Y.; Tavaré, Simon; Neal, David E.; Lynch, Andy G.; UK Prostate ICGC Group (2015-04-01) - Journal article
    Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent ...
  • Higher biodiversity is required to sustain multiple ecosystem processes across temperature regimes 

    Perkins, D.M.; Bailey, R.A.; Dossena, M.; Gamfeldt, L.; Reiss, J.; Trimmer, M.; Woodward, G. (2015-01) - Journal article
    Biodiversity loss is occurring rapidly worldwide, yet it is uncertain whether few or many species are required to sustain ecosystem functioning in the face of environmental change. The importance of biodiversity might be ...
  • Impacts of anthropogenic noise on marine life : publication patterns, new discoveries, and future directions in research and management 

    Williams, Robert; Wright, Andrew J; Ashe, Erin; Blight, LK; Bruintjes, R; Canessa, R; Clark, CW; Cullis-Suzuki, S; Dakin, DT; Erbe, C; Hammond, Philip Steven; Merchant, MD; O'Hara, PD; Purser, J; Radford, AN; Simpson, SD; Thomas, Len; Wale, MA (2015-10) - Journal article
    Anthropogenic underwater noise is now recognized as a world-wide problem, and recent studies have shown a broad range of negative effects in a variety of taxa. Underwater noise from shipping is increasingly recognized as ...
  • The importance of DNA methylation in prostate cancer development 

    Massie, Charles E.; Mills, Ian G.; Lynch, Andy G. (2017-02) - Journal item
    After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific ...
  • Inference from randomized (factorial) experiments 

    Bailey, Rosemary Anne (2017) - Journal article
    This is a contribution to the discussion of the interesting paper by Ding [Statist. Sci. 32 (2017) 331–345], which contrasts approaches attributed to Neyman and Fisher. I believe that Fisher’s usual assumption was ...
  • Integration of copy number and transcriptomics provides risk stratification in prostate cancer : a discovery and validation cohort study 

    Ross-Adams, H.; Lamb, A. D.; Dunning, M. J.; Halim, S.; Lindberg, J.; Massie, C. M.; Egevad, L. A.; Russell, R.; Ramos-Montoya, A.; Vowler, S. L.; Sharma, N. L.; Kay, J.; Whitaker, H.; Clark, J.; Hurst, R.; Gnanapragasam, V. J.; Shah, N. C.; Warren, A. Y.; Cooper, C. S.; Lynch, A. G.; Stark, R.; Mills, I. G.; Grönberg, H.; Neal, D. E.; Shaw, Greg; Hori, Satoshi; Baridi, Ajoeb; Tran, Maxine; Wadhwa, Karan; Nelson, Adam; Patel, Keval; Thomas, Benjamin; Luxton, Hayley; Gnanpragasam, Vincent; Doble, Andrew; Kastner, Christof; Aho, Tevita; Haynes, Beverley; Partridge, Wendy; Cromwell, Elizabeth; Sangrasi, Asif; Burge, Jo; George, Anne; Stearn, Sara; Corcoran, Marie; Coret, Hansley; Basnett, Gillian; Francis, Indu; Whitington, Thomas; Yuan, Yinyin; Rueda, Oscar; Hadfield, James; Howat, Will; Miller, Jodi; Brewer, Daniel; CamCaP Study Group (2015-09) - Journal article
    Background : Understanding the heterogeneous genotypes and phenotypes of prostate cancer is fundamental to improving the way we treat this disease. As yet, there are no validated descriptions of prostate cancer subgroups ...
  • Inter-annual and seasonal trends in cetacean distribution, density and abundance off southern California 

    Campbell, G.S.; Thomas, L.; Whitaker, K.; Douglas, A.B.; Calambokidis, J.; Hildebrand, J.A. (2015-02) - Journal article
    Trends in cetacean density and distribution off southern California were assessed through visual line-transect surveys during thirty-seven California Cooperative Oceanic Fisheries Investigations (CalCOFI) cruises from July ...
  • Lengths of words in transformation semigroups generated by digraphs 

    Cameron, P. J.; Castillo-Ramirez, A.; Gadouleau, M.; Mitchell, J. D. (2017-02) - Journal article
    Given a simple digraph D on n vertices (with n≥2), there is a natural construction of a semigroup of transformations ⟨D⟩. For any edge (a, b) of D, let a→b be the idempotent of rank n−1 mapping a to b and fixing all vertices ...
  • Measuring temporal trends in biodiversity 

    Buckland, S. T.; Yuan, Y.; Marcon, Eric (2017-08-12) - Journal article
    In 2002, nearly 200 nations signed up to the 2010 target of the Convention for Biological Diversity, ‘to significantly reduce the rate of biodiversity loss by 2010’. In order to assess whether the target was met, it became ...
  • Mining human prostate cancer datasets : the “camcAPP” shiny app 

    Dunning, Mark J.; Vowler, Sarah L.; Lalonde, Emilie; Ross-Adams, Helen; Boutros, Paul; Mills, Ian G.; Lynch, Andy G.; Lamb, Alastair D. (2017-03) - Journal item
  • Mixture models for distance sampling detection functions 

    Miller, David Lawrence; Thomas, Len (2015-03-20) - Journal article
    We present a new class of models for the detection function in distance sampling surveys of wildlife populations, based on finite mixtures of simple parametric key functions such as the half-normal. The models share many ...
  • Mobile element insertions are frequent in oesophageal adenocarcinomas and can mislead paired-end sequencing analysis 

    Paterson, Anna L.; Weaver, Jamie M. J.; Eldridge, Matthew D.; Tavare, Simon; Fitzgerald, Rebecca C.; Edwards, Paul A. W.; Lynch, Andy (2015-07-10) - Journal article
    Background: Mobile elements are active in the human genome, both in the germline and cancers, where they can mutate driver genes. Results: While analysing whole genome paired-end sequencing of oesophageal adenocarcinomas ...
  • Modeling the aggregated exposure and responses of bowhead whales Balaena mysticetus to multiple sources of anthropogenic underwater sound 

    Ellison, William T.; Racca, Roberto; Clark, Christopher W.; Streever, Bill; Frankel, Adam S.; Fleishman, Erica; Angliss, Robyn; Berger, Joel; Ketten, Darlene; Guerra, Melania; Leu, Matthias; McKenna, Megan; Sformo, Todd; Southall, Brandon; Suydam, Robert; Thomas, Len (2016-05-02) - Journal article
    Potential responses of marine mammals to anthropogenic underwater sound are usually assessed by researchers and regulators on the basis of exposure to a single, relatively loud sound source. However, marine mammals typically ...
  • Modelling group dynamic animal movement 

    Langrock, Roland; Hopcraft, Grant; Blackwell, Paul; Goodall, Victoria; King, Ruth; Niu, Mu; Patterson, Toby; Pedersen, Martin; Skarin, Anna; Schick, Robert Schilling (2014-02) - Journal article
    1). Group dynamics are a fundamental aspect of many species' movements. The need to adequately model individuals' interactions with other group members has been recognized, particularly in order to differentiate the role ...
  • Most primitive groups are full automorphism groups of edge-transitive hypergraphs 

    Babai, Laszlo; Cameron, Peter Jephson (2015-01-01) - Journal article
    We prove that, for a primitive permutation group G acting on a set of size n, other than the alternating group, the probability that Aut(X,YG) = G for a random subset Y of X, tends to 1 as n tends to infinity. So the ...
  • Most switching classes with primitive automorphism groups contain graphs with trivial groups 

    Cameron, Peter Jephson; Spiga, Pablo (2015-06) - Journal article
    The operation of switching a graph Gamma with respect to a subset X of the vertex set interchanges edges and non-edges between X and its complement, leaving the rest of the graph unchanged. This is an equivalence relation ...