Now showing items 41-60 of 416

  • Calcium ions alter monoamine oxidase A activity 

    Ramsay, Rona R.; Armstrong, Stephanie (Lulu, 2013) - Conference item
    Activation of the flavoprotein monoamine oxidase A (MAO A) by calcium ions has been reported in isolated mitochondria, in cell lines, and in vivo. Enhanced MAO A activity has been associated with a rise in oxidative damage ...
  • The calcium-binding protein EFhd2 modulates synapse formation in vitro and Is linked to human dementia 

    Borger, Eva; Herrmann, Abigail; Mann, David; Spires-Jones, Tara; Gunn-Moore, Frank J (2014-10) - Journal article
    EFhd2 is a calcium-binding adaptor protein that has been found to be associated with pathologically aggregated tau in the brain in Alzheimer disease and in a mouse model of frontotemporal dementia. EFhd2 has cell type–specific ...
  • Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties 

    Figuera-Losada, Mariana; Stathis, Marigo; Dorskind, Joelle M.; Thomas, Ajit G.; Bandaru, Veera Venkata Ratnam; Yoo, Seung-Wan; Westwood, Nicholas James; Rogers, Graeme Wayne; McArthur, Justin C.; Haughey, Norman J.; Slusher, Barbara S.; Rojas, Camilo (2015-05-26) - Journal article
    Ceramide is a bioactive lipid that plays an important role in stress responses leading to apoptosis, cell growth arrest and differentiation. Ceramide production is due in part to sphingomyelin hydrolysis by sphingomyelinases. ...
  • Cas6 specificity and CRISPR RNA loading in a complex CRISPR-Cas system 

    Sokolowski, Richard David; Graham, Shirley; White, Malcolm F (2014-06-02) - Journal article
    CRISPR-Cas is an adaptive prokaryotic immune system, providing protection against viruses and other mobile genetic elements. In type I and type III CRISPR-Cas systems, CRISPR RNA (crRNA) is generated by cleavage of a primary ...
  • Catalyst selective and regiodivergent O- to C- or N-carboxyl transfer of pyrazolyl carbonates : synthetic and computational studies 

    Gould, Eoin; Walden, Daniel M.; Kasten, Kevin; Johnston, Ryne C.; Wu, Jiufeng; Slawin, Alexandra M. Z.; Mustard, Thomas J. L.; Johnston, Brittany; Davies, Tony; Ha-Yeon Cheong, Paul; Smith, Andrew D. (2014-07-03) - Journal article
    The regiodivergent O- to C- or N-carboxyl transfer of pyrazolyl carbonates is described, with DMAP giving preferential N-carboxylation and triazolinylidenes promoting selective C-carboxylation (both with up to >99 : 1 ...
  • Catalytic depolymerisation of isolated lignins to fine chemicals using a Pt/alumina catalyst : part 1—impact of the lignin structure 

    Bouxin, Florent P.; McVeigh, Ashley; Tran, Fanny; Westwood, Nicholas James; Jarvis, Michael C.; Jackson, S. David (2015-02-01) - Journal article
    Four lignin preparations with different contents of alkyl aryl ether bonds were depolymerised using an alumina supported platinum catalyst. The results showed that the proportion of β-O-4 linkages is the crucial factor for ...
  • Catalytic stereoselective [2,3]-rearrangement reactions 

    West, Thomas Henry; Spoehrle, Stephanie Suzanne Madeleine; Kasten, Kevin; Taylor, James Edward; Smith, Andrew David (2015) - Journal article
    [2,3]-Sigmatropic rearrangement processes of allylic ylides or their equivalents can be applied to a variety of different substrates and generate products of wide interest and applicability to organic synthesis. This review ...
  • CCCTC-binding factor recruitment to the early region of the human papillomavirus type 18 genome regulates viral oncogene expression 

    Paris, Christian; Pentland, Ieisha; Groves, Ian; Roberts, David C; Powis, Simon J; Coleman, Nicholas; Roberts, Sally; Parish, Joanna L (2015-05) - Journal article
    Host cell differentiation-dependent regulation of human papillomavirus (HPV) gene expression is required for productive infection. The host cell CCCTC-binding factor (CTCF) functions in genome-wide chromatin organization ...
  • Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy 

    Clelland, Allyson Kara; Bales, Alexandra Beatrice Elizabeth; Sleeman, Judith Elizabeth (2012-06-01) - Journal article
    It is becoming increasingly clear that defects in RNA metabolism can lead to disease. Spinal muscular atrophy (SMA), a leading genetic cause of infant mortality, results from insufficient amounts of survival motor neuron ...
  • Characterisation of a Holliday junction-resolving enzyme from Schizosaccharomyces pombe 

    White, Malcolm Frederick; Lilley, DMJ (1997-11) - Journal article
    The rearrangement and repair of DNA by homologous recombination involves the creation of Holliday junctions, which are cleaved by a class of junction-specific endonucleases to generate recombinant duplex DNA products, Only ...
  • Chemistry in Bioinformatics 

    Murray-Rust, P; Mitchell, John B. O.; Rzepa, H S (2005-06-07) - Journal article
    Chemical information is now seen as critical for most areas of life sciences. But unlike Bioinformatics, where data is openly available and freely re-usable, most chemical information is closed and cannot be re-distributed ...
  • Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins 

    Handing, Katarzyna B.; Shabalin, Ivan G; Kassaar, Omar; Khazaipoul, Siavash; Blindauer, Claudia A; Stewart, Alan James; Chruszcz, Maksymilian; Minor, Wladek (2016-11-01) - Journal article
    Zinc is an essential nutrient in the body; it is required for the catalytic activity of many hundreds of human enzymes and virtually all biological processes, therefore its homeostasis and trafficking is of crucial interest. ...
  • cis-Cyclopropylamines as mechanism-based inhibitors of Monoamine Oxidases 

    Malcomson, Thomas; Kelekci, Kemal; Borrello, Maria T.; Ganesan, A.; Semina, Elena; De Kimpe, Norbert; Mangelinckx, Sven; Ramsay, Rona R. (2015-08) - Journal article
    Cyclopropylamines, inhibitors of monoamine oxidases (MAO) and lysine-specific demethylase (LSD1), provide a useful structural scaffold for the design of mechanism-based inhibitors for the therapy of depression and cancer. ...
  • A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro 

    Zhou, Linna; Stewart, Gavin; Rideau, Emeline; Westwood, Nicholas James; Smith, Terry K (2013-02-14) - Journal article
    Recently, the World Health Organization approved the nifurtimox–eflornithine combination therapy for the treatment of human African trypanosomiasis, renewing interest in nitroheterocycle therapies for this and associated ...
  • CMLSnap : Animated reaction mechanisms 

    Holliday, G L; Mitchell, John B. O.; Murray-Rust, P (2004-10-26) - Journal article
    Reactions with many steps can be represented by a single XML-based table of the atoms, bonds and electrons. For each step the complete Chemical Markup Language 1 representation of all components is obtained and a snapshot ...
  • Codon pair bias and viral vaccine design 

    Luke, Garry Alec; Pathania, Uday Singh; Tulloch, Fiona Ashley; Ryan, Martin Denis (2013-06-29) - Journal article
    Live attenuated vaccines (LAVs) have prevented morbidity and mortality against a number of important viral diseases (such as smallpox and polio) via long-lived humoral and cell-mediated immunity. Unlike inactivated, subunit ...
  • Common phenolic metabolites of flavonoids, but not their unmetabolized precursors, reduce the secretion of vascular cellular adhesion molecules by human endothelial cells 

    Warner, Emily F; Zhang, Qingzhi; Raheem, K. Saki; O'Hagan, David; O’Connell, Maria A.; Kay, Colin D (2016-03-01) - Journal article
    Background: Flavonoids have been implicated in the prevention of cardiovascular disease; however, their mechanisms of action have yet to be elucidated, possibly because most previous in vitro studies have used supraphysiological ...
  • Communication and re-use of chemical information in bioscience 

    Murray-Rust, P; Mitchell, John B. O.; Rzepa, H S (2005-07-18) - Journal item
    The current methods of publishing chemical information in bioscience articles are analysed. Using 3 papers as use-cases, it is shown that conventional methods using human procedures, including cut-and-paste are time-consuming ...
  • Community-acquired pneumonia and tuberculosis : differential diagnosis and the use of fluoroquinolones 

    Grossman, R.F.; Hsueh, P.-R.; Gillespie, S.H.; Blasi, F. (2014-01-01) - Journal article
    The respiratory fluoroquinolones moxifloxacin, gemifloxacin, and high-dose levofloxacin are recommended in guidelines for effective empirical antimicrobial therapy of community-acquired pneumonia (CAP). The use of these ...
  • A compact Airy beam light sheet microscope with a tilted cylindrical lens 

    Yang, Zhengyi; Prokopas, Martynas; Nylk, Jonathan; Coll Llado, Clara; Gunn-Moore, Frank J; Ferrier, David Ellard Keith; Vettenburg, Tom; Dholakia, Kishan (2014-10-01) - Journal article
    Light-sheet imaging is rapidly gaining importance for imaging intact biological specimens. Many of the latest innovations rely on the propagation-invariant Bessel or Airy beams to form an extended light sheet to provide ...