Now showing items 48-67 of 538

  • Bunyaviruses and the type I interferon system 

    Elliott, Richard Michael; Weber, F (2009-11-23) - Journal article
    The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop ...
  • Bypassing the proline/thiazoline requirement of the macrocyclase PatG 

    Oueis, E.; Stevenson, H.; Jaspars, M.; Westwood, N. J.; Naismith, J. H. (2017-11-25) - Journal article
    Biocatalysis is a fast developing field in which an enzyme’s natural capabilities are harnessed or engineered for synthetic chemistry. The enzyme PatG is an extremely promiscuous macrocyclase enzyme tolerating both non-natural ...
  • The Ca2+ sensor protein Swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons 

    Purohit, P; Perez-Branguli, F; Prots, I; Borger, Eva; Gunn-Moore, Frank J; Welzel, O; Loy, K; Wenzel, EM; Gromer, TW; Brachs, S; Holzer, M; Buslei, R; Fritsch, K; Regensburger, M; Bohm, KJ; Winner, B; Mielenz, D (2014-08-18) - Journal article
    Swiprosin-1/EFhd2 (EFhd2) is a cytoskeletal Ca2+ sensor protein strongly expressed in the brain. It has been shown to interact with mutant tau, which can promote neurodegeneration, but nothing is known about the physiological ...
  • The Cajal body and the nucleolus : “in a relationship” or “it's complicated”? 

    Trinkle-Mulcahy, Laura; Sleeman, Judith E. (2016-09-23) - Journal item
    From their initial identification as 'nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy. In this review, we seek to place ...
  • Calcium ions alter monoamine oxidase A activity 

    Ramsay, Rona R.; Armstrong, Stephanie (Lulu, 2013) - Conference item
    Activation of the flavoprotein monoamine oxidase A (MAO A) by calcium ions has been reported in isolated mitochondria, in cell lines, and in vivo. Enhanced MAO A activity has been associated with a rise in oxidative damage ...
  • The calcium-binding protein EFhd2 modulates synapse formation in vitro and Is linked to human dementia 

    Borger, Eva; Herrmann, Abigail; Mann, David; Spires-Jones, Tara; Gunn-Moore, Frank J (2014-10) - Journal article
    EFhd2 is a calcium-binding adaptor protein that has been found to be associated with pathologically aggregated tau in the brain in Alzheimer disease and in a mouse model of frontotemporal dementia. EFhd2 has cell type–specific ...
  • Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties 

    Figuera-Losada, Mariana; Stathis, Marigo; Dorskind, Joelle M.; Thomas, Ajit G.; Bandaru, Veera Venkata Ratnam; Yoo, Seung-Wan; Westwood, Nicholas James; Rogers, Graeme Wayne; McArthur, Justin C.; Haughey, Norman J.; Slusher, Barbara S.; Rojas, Camilo (2015-05-26) - Journal article
    Ceramide is a bioactive lipid that plays an important role in stress responses leading to apoptosis, cell growth arrest and differentiation. Ceramide production is due in part to sphingomyelin hydrolysis by sphingomyelinases. ...
  • Cas6 specificity and CRISPR RNA loading in a complex CRISPR-Cas system 

    Sokolowski, Richard David; Graham, Shirley; White, Malcolm F (2014-06-02) - Journal article
    CRISPR-Cas is an adaptive prokaryotic immune system, providing protection against viruses and other mobile genetic elements. In type I and type III CRISPR-Cas systems, CRISPR RNA (crRNA) is generated by cleavage of a primary ...
  • Catalyst selective and regiodivergent O- to C- or N-carboxyl transfer of pyrazolyl carbonates : synthetic and computational studies 

    Gould, Eoin; Walden, Daniel M.; Kasten, Kevin; Johnston, Ryne C.; Wu, Jiufeng; Slawin, Alexandra M. Z.; Mustard, Thomas J. L.; Johnston, Brittany; Davies, Tony; Ha-Yeon Cheong, Paul; Smith, Andrew D. (2014-07-03) - Journal article
    The regiodivergent O- to C- or N-carboxyl transfer of pyrazolyl carbonates is described, with DMAP giving preferential N-carboxylation and triazolinylidenes promoting selective C-carboxylation (both with up to >99 : 1 ...
  • Catalytic depolymerisation of isolated lignins to fine chemicals using a Pt/alumina catalyst : part 1—impact of the lignin structure 

    Bouxin, Florent P.; McVeigh, Ashley; Tran, Fanny; Westwood, Nicholas James; Jarvis, Michael C.; Jackson, S. David (2015-02-01) - Journal article
    Four lignin preparations with different contents of alkyl aryl ether bonds were depolymerised using an alumina supported platinum catalyst. The results showed that the proportion of β-O-4 linkages is the crucial factor for ...
  • Catalytic enantioselective [2,3]-rearrangements of allylic ammonium ylides : a mechanistic and computational study 

    West, Thomas H.; Walden, Daniel M.; Taylor, James E.; Brueckner, Alexander C.; Johnston, Ryne C.; Cheong, Paul Ha-Yeon; Lloyd-Jones, Guy C.; Smith, Andrew D. (2017-03-29) - Journal article
    A mechanistic study of the isothiourea-catalysed enantioselective [2,3]-rearrangement of allylic ammonium ylides is described. Reaction kinetic analyses using 19F NMR and density functional theory computations have elucidated ...
  • The catalytic mechanism of the marine-derived macrocyclase PatGmac 

    Brás, Natércia F.; Ferreira, Pedro; Calixto, Ana R.; Jaspars, Marcel; Houssen, Wael; Naismith, Jim; Fernandes, Pedro A.; Ramos, Maria J. (2016-09-01) - Journal article
    Cyclic peptides are a class of compounds with high therapeutic potential, possessing bioactivities including antitumor and antiviral (including anti-HIV). Despite their desirability, efficient design and production of these ...
  • Catalytic stereoselective [2,3]-rearrangement reactions 

    West, Thomas Henry; Spoehrle, Stephanie Suzanne Madeleine; Kasten, Kevin; Taylor, James Edward; Smith, Andrew David (2015) - Journal article
    [2,3]-Sigmatropic rearrangement processes of allylic ylides or their equivalents can be applied to a variety of different substrates and generate products of wide interest and applicability to organic synthesis. This review ...
  • CCCTC-binding factor recruitment to the early region of the human papillomavirus type 18 genome regulates viral oncogene expression 

    Paris, Christian; Pentland, Ieisha; Groves, Ian; Roberts, David C; Powis, Simon J; Coleman, Nicholas; Roberts, Sally; Parish, Joanna L (2015-05) - Journal article
    Host cell differentiation-dependent regulation of human papillomavirus (HPV) gene expression is required for productive infection. The host cell CCCTC-binding factor (CTCF) functions in genome-wide chromatin organization ...
  • Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy 

    Clelland, Allyson Kara; Bales, Alexandra Beatrice Elizabeth; Sleeman, Judith Elizabeth (2012-06-01) - Journal article
    It is becoming increasingly clear that defects in RNA metabolism can lead to disease. Spinal muscular atrophy (SMA), a leading genetic cause of infant mortality, results from insufficient amounts of survival motor neuron ...
  • Characterisation of a Holliday junction-resolving enzyme from Schizosaccharomyces pombe 

    White, Malcolm Frederick; Lilley, DMJ (1997-11) - Journal article
    The rearrangement and repair of DNA by homologous recombination involves the creation of Holliday junctions, which are cleaved by a class of junction-specific endonucleases to generate recombinant duplex DNA products, Only ...
  • Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates 

    Melo Czekster, Clarissa; Ludewig, Hannes; McMahon, Stephen A.; Naismith, James H. (2017-10-19) - Journal article
    Peptide macrocycles are promising therapeutic molecules because they are protease resistant, structurally rigid, membrane permeable and capable of modulating protein-protein interactions. Here, we report the characterization ...
  • Chemistry in Bioinformatics 

    Murray-Rust, P; Mitchell, John B. O.; Rzepa, H S (2005-06-07) - Journal article
    Chemical information is now seen as critical for most areas of life sciences. But unlike Bioinformatics, where data is openly available and freely re-usable, most chemical information is closed and cannot be re-distributed ...
  • Ciproxifan, a H3 receptor inverse agonist, reversibly inhibits human monoamine oxidase A and B 

    Hagenow, Stefanie; Stasiak, A.; Ramsay, Rona R.; Stark, Holger (2017-01-13) - Journal article
    Ciproxifan is a well-investigated histamine H3 receptor (H3R) inverse agonist/antagonist, showing an exclusively high species-specific affinity at rodent compared to human H3R. It is well studied as reference compound for ...
  • Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins 

    Handing, Katarzyna B.; Shabalin, Ivan G; Kassaar, Omar; Khazaipoul, Siavash; Blindauer, Claudia A; Stewart, Alan James; Chruszcz, Maksymilian; Minor, Wladek (2016-11-01) - Journal article
    Zinc is an essential nutrient in the body; it is required for the catalytic activity of many hundreds of human enzymes and virtually all biological processes, therefore its homeostasis and trafficking is of crucial interest. ...